Chemical architecture and applications of nucleic acid derivatives containing 1,2,3-triazole functionalities synthesized via click chemistry.
Chemical architecture and applications of nucleic acid derivatives containing 1,2,3-triazole functionalities synthesized via click chemistry.
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通过点击化学合成的1,2,3-三唑功能的核酸衍生物的化学结构和应用。
DOI：
10.3390/molecules171112665
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发表时间：
2012-10-26
期刊：
影响因子：
--
通讯作者：
Desaulniers JP
中科院分区：
文献类型：
--
作者：
Efthymiou T;Gong W;Desaulniers JP
有相当多的注意力集中在用稳健的官能团化学修饰核酸以改变其性质。自从铜辅助的叠氮化物-炔环加成（CuAAC）的突破以来，已经有几篇报道描述了用于潜在的下游基于DNA和RNA的应用的新型三唑修饰的核酸衍生物的合成和性质。这篇综述将着重于突出代表性的新的核酸分子结构，已通过“点击”叠氮化物-炔环加成合成。这些衍生物中的许多显示出对于涉及酶促转化、核酸杂交、分子标记和纯化以及基因沉默的各种应用的相容性。这些应用程序的细节进行了讨论。总之，用三唑官能化的核酸类似物的未来是有希望的。
There is considerable attention directed at chemically modifying nucleic acids with robust functional groups in order to alter their properties. Since the breakthrough of copper-assisted azide-alkyne cycloadditions (CuAAC), there have been several reports describing the synthesis and properties of novel triazole-modified nucleic acid derivatives for potential downstream DNA- and RNA-based applications. This review will focus on highlighting representative novel nucleic acid molecular structures that have been synthesized via the “click” azide-alkyne cycloaddition. Many of these derivatives show compatibility for various applications that involve enzymatic transformation, nucleic acid hybridization, molecular tagging and purification, and gene silencing. The details of these applications are discussed. In conclusion, the future of nucleic acid analogues functionalized with triazoles is promising.
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