Design of a biofluid-absorbing bioactive sandwich-structured Zn-Si bioceramic composite wound dressing for hair follicle regeneration and skin burn wound healing.
Design of a biofluid-absorbing bioactive sandwich-structured Zn-Si bioceramic composite wound dressing for hair follicle regeneration and skin burn wound healing.
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用于毛囊再生和皮肤烧伤创面愈合的生物流体吸收生物活性夹层结构锌硅生物陶瓷复合伤口敷料的设计
DOI：
10.1016/j.bioactmat.2020.12.006
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发表时间：
2021-07
影响因子：
18.9
通讯作者：
Chang J
中科院分区：
文献类型：
--
作者：
Zhang Z;Li W;Liu Y;Yang Z;Ma L;Zhuang H;Wang E;Wu C;Huan Z;Guo F;Chang J
深度烧伤皮肤损伤通常严重损害真皮层，毛囊丢失，难以再生。此外，严重烧伤往往伴有大量伤口渗出液，使伤口潮湿，容易感染，难以愈合。因此，研制创面敷料清除创面渗出液，促进毛囊再生具有重要的临床意义。在这项研究中，使用亲水性硅酸锌生物陶瓷（Hardystonite，ZnCS）和疏水性聚乳酸（PLA），通过热压成型制备具有Janus膜性能的弹性结构伤口敷料（SWD）。这种独特的有机/无机Janus膜结构显示出优异的渗液吸收性能，并有效地创造了干燥的伤口环境。同时，ZnCS生物陶瓷颗粒的掺入使敷料具有通过释放Zn 2+和SiO 32 −离子促进毛囊再生和伤口愈合的生物活性，伤口敷料的这种生物活性主要归因于Zn 2+和SiO 32 −的协同作用，促进毛囊细胞的募集、存活和分化。本研究表明，利用Janus膜和不同类型的生物活性离子的协同作用是设计用于烧伤创面愈合的创面敷料的有效途径。使用ZnCS陶瓷粉末和PLA纤维膜（ZnCS-SWD）构建了具有弹性结构的伤口敷料。ZnCS-SWD具有Janus膜特性，可将伤口渗出液从伤口床单向吸收到敷料。Zn ~（2+）和SiO_（32-）离子的组合被发现具有促进烧伤创面愈合的协同效应。
The deep burn skin injures usually severely damage the dermis with the loss of hair follicle loss, which are difficult to regenerate. Furthermore, severe burns often accompanied with large amount of wound exudates making the wound moist, easily infected, and difficult to heal. Therefore, it is of great clinical significance to develop wound dressings to remove wound exudates and promote hair follicle regeneration. In this study, a sandwich-structured wound dressing (SWD) with Janus membrane property was fabricated by hot compression molding using hydrophilic zinc silicate bioceramics (Hardystonite, ZnCS) and hydrophobic polylactic acid (PLA). This unique organic/inorganic Janus membrane structure revealed excellent exudate absorption property and effectively created a dry wound environment. Meanwhile, the incorporation of ZnCS bioceramic particles endowed the dressing with the bioactivity to promote hair follicle regeneration and wound healing through the release of Zn2+ and SiO32− ions, and this bioactivity of the wound dressing is mainly attributed to the synergistic effect of Zn2+ and SiO32− to promote the recruitment, viability, and differentiation of hair follicle cells. Our study demonstrates that the utilization of the Janus membrane and synergistic effect of different type bioactive ions are effective approaches for the design of wound dressings for burn wound healing. A sandwich-structured wound dressing is constructed using ZnCS ceramic powder and PLA fiber membrane (ZnCS-SWD). ZnCS-SWD has Janus membrane property to absorb wound exudate unidirectionally from wound bed to the dressing. The combination of Zn2+ and SiO32- ions is found to have a synergistic effect to promote burn wound healing.
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影响因子：
2.8
作者：
Ayaz, Furkan;Eker-Develi, Elif;Sahin, Merve
通讯作者：
Sahin, Merve
影响因子：
2.2
作者：
Chakrabarti, Bornali;Bairagya, Hridoy R.;Sekar, K.
通讯作者：
Sekar, K.
影响因子：
4.6
作者：
Choi, Mira;Choi, Soon-Jin;Kwon, Ohsang
通讯作者：
Kwon, Ohsang
影响因子：
3.6
作者：
Kamp, H;Geilen, CC;Blume-Peytavi, U
通讯作者：
Blume-Peytavi, U
影响因子：
6
作者：
Abdal-Hay, Abdalla;Memic, Adnan;Ivanovski, Saso
通讯作者：
Ivanovski, Saso