Serum ferritin concentrations and body iron stores in a multicenter, multiethnic primary-care population.
Serum ferritin concentrations and body iron stores in a multicenter, multiethnic primary-care population.
复制标题
DOI：
10.1002/ajh.21179
复制
发表时间：
2008-08
影响因子：
12.8
通讯作者：
Dawkins, Fitzroy W.
中科院分区：
文献类型：
--
作者：
Gordeuk, Victor R.;Reboussin, David M.;McLaren, Christine E.;Barton, James C.;Acton, Ronald T.;McLaren, Gordon D.;Harris, Emily L.;Reiss, Jacob A.;Adams, Paul C.;Speechley, Mark;Phatak, Pradyumna D.;Sholinsky, Phyliss;Eckfeldt, John H.;Chen, Wen-Pin;Passmore, Leah;Dawkins, Fitzroy W.
初级保健患者血清铁蛋白升高反映铁储备增加的频率尚不清楚(通常男性为0.8克，女性为0.4克)。遗传性血色素沉着症和铁过载筛查(继承者)研究筛查了101,168名初级保健参与者(44%高加索人，27%非裔美国人，14%亚洲人/太平洋岛民，13%西班牙人，2%其他人)。对333例HFE C282Y纯合子中的302例和1,920例血清铁蛋白>；300μg/L(男性)、>；200μg/L(女性)和转铁蛋白饱和度&50%(男性)、>；45%(女性)的1,375例非纯合子进行了临床随访。在评估时，对175例C282Y纯合子中的122例和1102例非输血血清铁蛋白升高的非纯合子中的122例进行了定量静脉采血。在高加索人群中，血清铁蛋白>；900μg/L纯合子的估计患病率为每10,000名男性中有20名男性和每10,000名女性中有4名女性；这一星座预测男性和女性的铁储备>；4g和>；2g。在评估中，血清铁蛋白>；900μg/L的非C282Y纯合子每10,000人中的估计患病率在高加索人中为7人，西班牙裔人中为13人，非裔美国人中为20人，亚洲人和太平洋岛民中为38人，这一星座预测铁储量>；2 g但<；4 g。总而言之，血清铁蛋白>；900μg/L在最初血清铁蛋白和转铁蛋白饱和度均升高后，预示着在多种族人群中铁储量略有增加，而不考虑HFE基因。男性C282Y纯合子的血清铁蛋白>；900μg/L是铁储存适度增加的预测指标。
How often elevated serum ferritin in primary-care patients reflects increased iron stores (normally 0.8 g in men, 0.4 g in women) is not known. The Hereditary Hemochromatosis and Iron Overload Screening (HEIRS) study screened 101,168 primary-care participants (44% Caucasians, 27% African-Americans, 14% Asians/Pacific Islanders, 13% Hispanics, 2% others). Follow-up clinical evaluation was performed in 302 of 333 HFE C282Y homozygotes regardless of iron measures and 1,375 of 1,920 nonhomozygotes with serum ferritin >300 μg/L (men), >200 μg/L (women) and transferrin saturation >50% (men), >45% (women). Quantitative phlebotomy was conducted in 122 of 175 C282Y homozygotes and 122 of 1,102 nonhomozygotes with non-transfusional serum ferritin elevation at evaluation. The estimated prevalence in the Caucasian population of C282Y homozygotes with serum ferritin >900 μg/L at evaluation was 20 per 10,000 men and 4 per 10,000 women; this constellation was predictive of iron stores >4 g in men and >2 g in women. The estimated prevalence per 10,000 of non-C282Y homozygotes with serum ferritin >900 μg/L at evaluation was 7 among Caucasians, 13 among Hispanics, 20 among African Americans, and 38 among Asians and Pacific Islanders, and this constellation was predictive of iron stores >2 g but <4 g. In conclusion, serum ferritin >900 μg/L after initial elevations of both serum ferritin and transferrin saturation is predictive of mildly increased iron stores in multiple ethnic populations regardless of HFE genotype. Serum ferritin >900 μg/L in male C282Y homozygotes is predictive of moderately increased iron stores.
登录
查看更多内容
影响因子：
29.4
作者：
DIBISCEGLIE, AM;AXIOTIS, CA;BACON, BR
通讯作者：
BACON, BR
影响因子：
15.9
作者：
HASKINS, D;STEVENS, AR;FINCH, CA
通讯作者：
FINCH, CA
影响因子：
158.5
作者：
Adams, PC;Reboussin, DM;Thomson, E
通讯作者：
Thomson, E
影响因子：
39.2
作者：
BALCERZAK, SP;WESTERMAN, MP;TAYLOR, FH
通讯作者：
TAYLOR, FH
影响因子：
16.2
作者：
Acton, Ronald T.;Reboussin, David M.;Sholinsky, Phyliss
通讯作者：
Sholinsky, Phyliss