Seizures and epilepsy in Alzheimer's disease.
Seizures and epilepsy in Alzheimer's disease.
复制标题
DOI：
10.1111/j.1755-5949.2011.00251.x
复制
发表时间：
2012-04
影响因子：
5.5
通讯作者：
Scarmeas N
中科院分区：
文献类型：
--
作者：
Friedman D;Honig LS;Scarmeas N
许多研究表明，阿尔茨海默病（AD）患者发生癫痫发作和癫痫的风险增加。然而，报告的癫痫发作的患病率和发生率以及癫痫发作与疾病指标（如严重程度、结局和进展）的关系在研究之间差异很大。关于AD患者癫痫发作主题的现有临床和流行病学数据的文献综述。我们回顾了癫痫发作的发生率和类型，癫痫发作的危险因素，脑电图（EEG）研究和治疗反应。最后，我们考虑的局限性和方法问题。AD患者中报告的癫痫发作患病率和发生率存在相当大的差异-报告的终生患病率为1.5 - 64%。最近，前瞻性和更大规模的研究一般报告率较低。一些但不是所有的研究都注意到癫痫发作风险随着痴呆严重程度的增加或AD发病年龄的增加而增加。全身性惊厥发作是最常报告的类型，但通常历史信息是用于确定癫痫发作类型的唯一依据，癫痫发作的表现可能难以与痴呆患者常见的其他行为区分开来。EEG很少进行和报告。关于AD癫痫发作治疗的数据极其有限。同样，癫痫发作和AD认知障碍之间的关系也不清楚。关于AD中癫痫发作和癫痫的文献，包括诊断、风险因素和治疗反应，存在方法学限制和空白。
Many studies have shown that patients with Alzheimer’s disease (AD) are at increased risk for developing seizures and epilepsy. However, reported prevalence and incidence of seizures and relationship of seizures to disease measures such as severity, outcome and progression vary widely between studies. Literature review of the available clinical and epidemiological data on the topic of seizures in patients with AD. We review seizure rates and types, risk factors for seizures, electroencephalogram (EEG)studies, and treatment responses. Finally, we consider limitations and methodological issues. There is considerable variability in the reported prevalence and incidence of seizures in patients with AD - with reported lifetime prevalence rates of 1.5 - 64%. More recent, prospective, and larger studies in general report lower rates. Some, but not all, studies have noted increased seizure risk with increasing dementia severity or with younger age of AD onset. Generalized convulsive seizures are the most commonly reported type, but often historical information is the only basis used to determine seizure type and the manifestation of seizures may be difficult to distinguish from other behaviors common in demented patients. EEG has infrequently been performed and reported. Data on treatment of seizures in AD are extremely limited. Similarly, the relationship between seizures and cognitive impairment in AD is unclear. The literature on seizures and epilepsy in AD, including diagnosis, risk factors, and response to treatment suffers from methodological limitations and gaps.
登录
查看更多内容
影响因子：
9.9
作者：
HEYMAN, A;WILKINSON, WE;GWYTHER, LP
通讯作者：
GWYTHER, LP
影响因子：
5.6
作者：
LUHDORF, K;JENSEN, LK;PLESNER, AM
通讯作者：
PLESNER, AM
影响因子：
9.9
作者：
Hesdorffer, DC;Hauser, WA;Rocca, WA
通讯作者：
Rocca, WA
影响因子：
5.6
作者：
HAUSER, WA;ANNEGERS, JF;KURLAND, LT
通讯作者：
KURLAND, LT
影响因子：
2.5
作者：
Del Vecchio, RA;Gold, LH;Hyde, LA
通讯作者：
Hyde, LA