Cognitive control and white matter callosal microstructure in methamphetamine-dependent subjects: a diffusion tensor imaging study.
Cognitive control and white matter callosal microstructure in methamphetamine-dependent subjects: a diffusion tensor imaging study.
复制标题
DOI：
10.1016/j.biopsych.2008.08.004
复制
发表时间：
2009-01-15
影响因子：
10.6
通讯作者：
Leamon, Martin H.
中科院分区：
文献类型：
--
作者：
Salo, Ruth;Nordahl, Thomas E.;Buonocore, Michael H.;Natsuaki, Yutaka;Waters, Christy;Moore, Charles D.;Galloway, Gantt P.;Leamon, Martin H.
Methamphetamine (MA) abuse causes damage to structures within the human cerebrum, with particular susceptibility to white matter (WM). Abnormalities have been reported in anterior regions with less evidence of changes in posterior regions. MA abusers have also shown deficits on attention tests that measure response conflict and cognitive control. We examined cognitive control using a computerized measure of the Stroop selective attention task and indices of WM microstructure obtained from diffusion tensor imaging (DTI) in the callosal genu and splenium of 37 currently abstinent MA abusers and 17 non-substance abusing controls. Measurements of Fractional Anisotropy (FA), apparent diffusion coefficient (ADC) of callosal fibers and diffusion tensor eigenvalues were obtained in all subjects. The MA abusers exhibited greater Stroop reaction time interference (i.e., reduced cognitive control) [p=.04] compared to controls. After correcting for multiple comparisons, FA within the genu correlated significantly with measures of cognitive control in the MA abusers [p=.04, bonferroni corrected] but not in controls [p=.26]. Group differences in genu, but not splenium, FA were trend significant [p=.09]. MA abuse appears to alter anterior callosal WM microstructure with less evidence of change within posterior callosal WM microstructure. DTI indices within the genu, but not splenium, correlated with measures of cognitive control in chronic MA abusers.
登录
查看更多内容
DOI：
10.1196/annals.1340.024
发表时间：
2005-01-01
期刊：
WHITE MATTER IN COGNITIVE NEUROSCIENCE: ADVANCES IN DIFFUSION TENSOR IMAGING AND ITS APPLICATIONS
影响因子：
--
作者：
Kubicki, M;Westin, CF;Shenton, ME
通讯作者：
Shenton, ME
影响因子：
11
作者：
Foong, J;Maier, M;Ron, MA
通讯作者：
Ron, MA
DOI：
10.1017/sl461145706007395
发表时间：
2007-12-01
影响因子：
4.8
作者：
Chung, Ain;Lyoo, In Kyoon;Renshaw, Perry F.
通讯作者：
Renshaw, Perry F.
影响因子：
1.7
作者：
Aboitiz, F;Rodriguez, E;Zaidel, E
通讯作者：
Zaidel, E
影响因子：
17.7
作者：
Kalivas, PW;Volkow, ND
通讯作者：
Volkow, ND