Isomer profiles of perfluorochemicals in matched maternal, cord, and house dust samples: manufacturing sources and transplacental transfer.
Isomer profiles of perfluorochemicals in matched maternal, cord, and house dust samples: manufacturing sources and transplacental transfer.
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DOI：
10.1289/ehp.1003265
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发表时间：
2011-11
影响因子：
10.4
通讯作者：
Martin JW
中科院分区：
文献类型：
--
作者：
Beesoon S;Webster GM;Shoeib M;Harner T;Benskin JP;Martin JW
背景：全氟化合物(PFC)可在普通人群和人类环境中检测到，包括室内粉尘。来源没有很好的特征，但同分异构体模式应该能够区分历史和当代的制造来源。尽管已知全氟辛烷磺酸(PFOS)和全氟辛酸(PFOA)对啮齿动物的发育毒性，但尚未检测到全氟辛烷磺酸(PFOS)和全氟辛酸(PFOA)的异构体特异性母婴转移。目的：我们阐明了电化学性(2001年逐步淘汰)和端粒(当代)PFC在粉尘中的相对贡献，并测量了全氟化链长度和异构体分支模式对经胎盘转运效率(TTE；基于母体和脐带血清浓度的比较)的影响。方法：采用同分异构体特异性高效液相色谱-串联质谱法，对18份家居尘埃、20份孕妇血清和20份脐带血清配对样品进行分析。结果：全氟辛烷酸异构体特征显示，在室内粉尘中，端粒来源占全氟辛酸总量的0-95%(中位数，31%)。这可能在一定程度上解释了为什么在一些国家，尽管逐步淘汰了电化学全氟辛酸，但血清全氟辛酸浓度没有下降。TTE数据表明，全氟辛烷磺酸(p<；0.01)和全氟辛烷磺酸(p=0.02)的总支链异构体比线形异构体更有效地穿过胎盘，并且全氟辛烷磺酸支链异构体的胎盘转移随着支化点靠近分子的磺酸盐(SO3-)端而增加。结论：结果表明，人类暴露于端粒全氟辛酸，但也应进行更大规模的研究，以说明饮食来源。全氟辛烷磺酸和全氟辛酸异构体在母亲和胎儿之间的暴露情况可能不同--这是围产期全氟辛烷磺酸流行病学研究的一个重要考虑因素。
Background: Perfluorochemicals (PFCs) are detectable in the general population and in the human environment, including house dust. Sources are not well characterized, but isomer patterns should enable differentiation of historical and contemporary manufacturing sources. Isomer-specific maternal–fetal transfer of PFCs has not been examined despite known developmental toxicity of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in rodents. Objectives: We elucidated relative contributions of electrochemical (phased out in 2001) and telomer (contemporary) PFCs in dust and measured how transplacental transfer efficiency (TTE; based on a comparison of maternal and cord sera concentrations) is affected by perfluorinated chain length and isomer branching pattern. Methods: We analyzed matching samples of house dust (n = 18), maternal sera (n = 20), and umbilical cord sera (n = 20) by isomer-specific high-performance liquid chromatography tandem mass spectrometry. Results: PFOA isomer signatures revealed that telomer sources accounted for 0–95% of total PFOA in house dust (median, 31%). This may partly explain why serum PFOA concentrations are not declining in some countries despite the phase-out of electrochemical PFOA. TTE data indicate that total branched isomers crossed the placenta more efficiently than did linear isomers for both PFOS (p < 0.01) and PFOA (p = 0.02) and that placental transfer of branched isomers of PFOS increased as the branching point moved closer to the sulfonate (SO3–) end of the molecule. Conclusions: Results suggest that humans are exposed to telomer PFOA, but larger studies that also account for dietary sources should be conducted. The exposure profile of PFOS and PFOA isomers can differ between the mother and fetus—an important consideration for perinatal epidemiology studies of PFCs.
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