A single nucleotide polymorphism of the neuropeptide B/W receptor-1 gene influences the evaluation of facial expressions.
A single nucleotide polymorphism of the neuropeptide B/W receptor-1 gene influences the evaluation of facial expressions.
复制标题
DOI：
10.1371/journal.pone.0035390
复制
发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Yamamoto M
中科院分区：
文献类型：
--
作者：
Watanabe N;Wada M;Irukayama-Tomobe Y;Ogata Y;Tsujino N;Suzuki M;Furutani N;Sakurai T;Yamamoto M
神经肽B/W受体-1 （NPBWR1）在啮齿类动物和人类的离散脑区表达，在包括杏仁核中央核在内的边缘系统中表达尤为强烈。最近，Nagata-Kuroiwa等人报道了Npbwr1 - / -小鼠在社交行为上的变化，这表明Npbwr1在社交互动的情绪反应中起着重要作用。人类NPBWR1基因在404核苷酸处具有单核苷酸多态性（404A>T; SNP rs33977775）。这种多态性导致了氨基酸Y135F的变化。体外实验结果表明，这种变化改变了受体的功能。我们研究了这种变化对四类情绪表情（愤怒、恐惧、快乐和中性）显示人脸刺激的情绪反应的影响。受试者看到这些面孔时的情绪水平是通过快乐效价、情绪唤醒和支配（V-A-D）量表来评定的。效价评价存在显著的基因型差异；无论面部表情的类别如何，404AT组比404AA组对面部表情的感知更愉快。对[V-A-D和面部表情]的每种组合的统计分析也表明，与404AA组相比，404AT组倾向于对愤怒的脸不那么顺从。因此，NPBWR1的单核苷酸多态性似乎在社会环境中影响人类行为。
Neuropeptide B/W receptor-1 (NPBWR1) is expressed in discrete brain regions in rodents and humans, with particularly strong expression in the limbic system, including the central nucleus of the amygdala. Recently, Nagata-Kuroiwa et al. reported that Npbwr1 −/− mice showed changes in social behavior, suggesting that NPBWR1 plays important roles in the emotional responses of social interactions. The human NPBWR1 gene has a single nucleotide polymorphism at nucleotide 404 (404A>T; SNP rs33977775). This polymorphism results in an amino acid change, Y135F. The results of an in vitro experiment demonstrated that this change alters receptor function. We investigated the effect of this variation on emotional responses to stimuli of showing human faces with four categories of emotional expressions (anger, fear, happiness, and neutral). Subjects' emotional levels on seeing these faces were rated on scales of hedonic valence, emotional arousal, and dominance (V-A-D). A significant genotype difference was observed in valence evaluation; the 404AT group perceived facial expressions more pleasantly than did the 404AA group, regardless of the category of facial expression. Statistical analysis of each combination of [V-A-D and facial expression] also showed that the 404AT group tended to feel less submissive to an angry face than did the 404AA group. Thus, a single nucleotide polymorphism of NPBWR1 seems to affect human behavior in a social context.
登录
查看更多内容
影响因子：
16.2
作者：
Breiter, HC;Etcoff, NL;Rosen, BR
通讯作者：
Rosen, BR
影响因子：
4.2
作者：
Anders, Silke;Eippert, Falk;Veit, Ralf
通讯作者：
Veit, Ralf
DOI：
10.1111/j.1749-6632.2010.05445.x
发表时间：
2010-01-01
期刊：
YEAR IN COGNITIVE NEUROSCIENCE 2010
影响因子：
--
作者：
Adolphs, Ralph
通讯作者：
Adolphs, Ralph
影响因子：
2.9
作者：
Kitamura, Yoji;Tanaka, Hirokazu;Sakurai, Takeshi
通讯作者：
Sakurai, Takeshi
影响因子：
3.2
作者：
Cunningham, WA;Raye, CL;Johnson, MK
通讯作者：
Johnson, MK