Electronic cigarette user plasma nicotine concentration, puff topography, heart rate, and subjective effects: Influence of liquid nicotine concentration and user experience.
Electronic cigarette user plasma nicotine concentration, puff topography, heart rate, and subjective effects: Influence of liquid nicotine concentration and user experience.
复制标题
DOI：
10.1037/pha0000140
复制
发表时间：
2017-10
影响因子：
2.3
通讯作者：
Eissenberg T
中科院分区：
文献类型：
--
作者：
Hiler M;Breland A;Spindle T;Maloney S;Lipato T;Karaoghlanian N;Shihadeh A;Lopez A;Ramôa C;Eissenberg T
电子烟（ECIG）尼古丁递送和其他效果可能取决于液体尼古丁浓度和用户体验。这项研究首次系统地研究了ECIG液体尼古丁浓度和用户体验对尼古丁输送、心率、抽吸地形和主观效果的影响。33名有ECIG经验的个体和31名有ECIG经验的吸烟者完成了四种实验室条件，包括两次10次抽吸（30秒IPI），其中3.3伏ECIG电池连接到1.5欧姆的“雾化器”（7.3瓦），充满1 ml ECIG液体。条件因液体尼古丁浓度而异：0、8、18或36 mg/ml。参与者的血浆尼古丁浓度与液体尼古丁浓度直接相关，并取决于用户体验，在每种活性尼古丁条件下，相对于ECIG初治吸烟者，ECIG经历者的平均血浆尼古丁增加显著更高。当使用36 mg/ml时，ECIG经历个体的平均血浆尼古丁增加为17.9 ng/ml（SD = 17.2），ECIG初治个体为6.9 ng/ml（SD = 7.1; p <0.05）。组间差异可能是由于有经验的ECIG使用者的抽吸时间较长：在各种条件下崩溃，ECIG使用者的平均抽吸持续时间为5.6秒（SD = 3.0），ECIG初治者为2.9秒（SD = 1.5）。ECIG使用还抑制了两组中的尼古丁/烟草戒断症状;戒断症状抑制的程度取决于液体尼古丁浓度和用户体验。这些和其他最近的结果表明，旨在限制ECIG尼古丁递送的有效政策将需要考虑除了液体尼古丁浓度之外的因素（例如，设备功率和用户行为）。
Electronic cigarette (ECIG) nicotine delivery and other effects may depend on liquid nicotine concentration and user experience. This study is the first to examine systematically the influence of ECIG liquid nicotine concentration and user experience on nicotine delivery, heart rate, puff topography, and subjective effects. Thirty-three ECIG-experienced individuals and 31 ECIG-aïve cigarette smokers completed four laboratory conditions that consisted of two, 10-puff bouts (30-second IPI) with a 3.3 volt ECIG battery attached to a 1.5 Ohm “cartomizer” (7.3 watts) filled with 1 ml ECIG liquid. Conditions differed by liquid nicotine concentration: 0, 8, 18, or 36 mg/ml. Participants’ plasma nicotine concentration was related directly to liquid nicotine concentration and dependent on user experience with significantly higher mean plasma nicotine increases observed in ECIG-experienced individuals relative to ECIG-naïve smokers in each active nicotine condition. When using 36 mg/ml, mean plasma nicotine increase for ECIG-experienced individuals was 17.9 ng/ml (SD = 17.2) and 6.9 (SD = 7.1; p < .05) for ECIG-naive. Between-group differences were likely due to longer puffs taken by experienced ECIG users: collapsed across condition, mean puff duration was 5.6 seconds (SD = 3.0) for ECIG-experienced and 2.9 (SD = 1.5) for ECIG-naive. ECIG-use also suppressed nicotine/tobacco abstinence symptoms in both groups; the magnitude of abstinence symptom suppression depended upon liquid nicotine concentration and user experience. These and other recent results suggest that effective policies intended to limit ECIG nicotine delivery will need to account for factors in addition to liquid nicotine concentration (e.g., device power and user behavior).
登录
查看更多内容
影响因子：
9.3
作者：
Cobb CO;Hendricks PS;Eissenberg T
通讯作者：
Eissenberg T
影响因子：
2.3
作者：
Evans, Sarah E.;Blank, Melissa;Eissenberg, Thomas
通讯作者：
Eissenberg, Thomas
影响因子：
3.4
作者：
FOULDS, J;STAPLETON, J;RUSSELL, MAH
通讯作者：
RUSSELL, MAH
影响因子：
3.4
作者：
Dawkins, Lynne E.;Kimber, Catherine F.;Corcoran, Olivia
通讯作者：
Corcoran, Olivia
影响因子：
4.7
作者：
Blank, Melissa D.;Disharoon, Steven;Eissenberg, Thomas
通讯作者：
Eissenberg, Thomas