The Integration of Human and Veterinary Studies for Better Understanding and Management of Crimean-Congo Haemorrhagic Fever.

The Integration of Human and Veterinary Studies for Better Understanding and Management of Crimean-Congo Haemorrhagic Fever.
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整合人类和兽医研究,以更好地了解和管理克里米亚-刚果出血热。

DOI:
10.3389/fimmu.2021.629636
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发表时间:
2021
影响因子:
7.3
通讯作者:
Belij-Rammerstorfer S
Belij-Rammerstorfer S
中科院分区:
医学2区
文献类型:
--
作者:
Gilbride C;Saunders J;Sharpe H;Maze EA;Limon G;Ludi AB;Lambe T;Belij-Rammerstorfer S

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由于动物宿主的人畜共患病溢出而发生的暴发继续突出了研究物种之间疾病界面的重要性。“一个健康”方针认识到人类和动物健康的相互依存关系以及环境的相互作用。通过更多地考虑这些关系,可以提高对人畜共患疾病的认识和预防,从而有可能改善各物种的健康状况。在这篇综述中,特别强调了新出现和爆发的病原体克里米亚-刚果出血热病毒(CCHFV),可导致严重的疾病,在人类。我们讨论了所做的努力,以更好地了解CCHF和整合兽医和人类研究这种病原体的重要性。此外,我们考虑使用密切相关的nairoviruses模型引起的人类疾病CCHFV。我们讨论了潜在的应用管理CCHFV传播的干预方法,以及如何这一概念可能有利于动物和人类健康。
Outbreaks that occur as a result of zoonotic spillover from an animal reservoir continue to highlight the importance of studying the disease interface between species. One Health approaches recognise the interdependence of human and animal health and the environmental interplay. Improving the understanding and prevention of zoonotic diseases may be achieved through greater consideration of these relationships, potentially leading to better health outcomes across species. In this review, special emphasis is given on the emerging and outbreak pathogen Crimean-Congo Haemorrhagic Fever virus (CCHFV) that can cause severe disease in humans. We discuss the efforts undertaken to better understand CCHF and the importance of integrating veterinary and human research for this pathogen. Furthermore, we consider the use of closely related nairoviruses to model human disease caused by CCHFV. We discuss intervention approaches with potential application for managing CCHFV spread, and how this concept may benefit both animal and human health.
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