Susceptibilities of nonhuman primates to chronic wasting disease.
Susceptibilities of nonhuman primates to chronic wasting disease.
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DOI：
10.3201/eid1509.090253
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发表时间：
2009-09
影响因子：
11.8
通讯作者：
Chesebro B
中科院分区：
文献类型：
--
作者：
Race B;Meade-White KD;Miller MW;Barbian KD;Rubenstein R;LaFauci G;Cervenakova L;Favara C;Gardner D;Long D;Parnell M;Striebel J;Priola SA;Ward A;Williams ES;Race R;Chesebro B
物种屏障可以保护人类免受这种疾病的侵害。慢性消耗性疾病（CWD）是一种传染性海绵状脑病，或朊病毒病，影响鹿，麋鹿和驼鹿。尽管可能接触过感染CWD的鹿，但人类对CWD的易感性仍未得到证实。我们使用2种非人灵长类动物，食蟹猴和松鼠猴，作为慢性消耗病易感性的人类模型。CWD通过脑内和口服途径接种到这两个物种中。松鼠猴脑内接种后，8株CWD分离株中的7株在33-53个月内诱导了临床消耗综合征。猴子的大脑表现出海绵状脑病和蛋白酶抗性朊蛋白（PrPres）诊断朊病毒病。经口感染后，2只松鼠猴在感染后69个月时在脑、脾和淋巴结中发现PrPres。相比之下，食蟹猴在感染后70个月未显示出临床疾病的证据。因此，这两个物种对CWD的敏感性不同。因为人类在进化上更接近猕猴而不是松鼠猴，所以他们也可能对慢性消耗病有抵抗力。
A species barrier may protect humans from this disease. Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy, or prion disease, that affects deer, elk, and moose. Human susceptibility to CWD remains unproven despite likely exposure to CWD-infected cervids. We used 2 nonhuman primate species, cynomolgus macaques and squirrel monkeys, as human models for CWD susceptibility. CWD was inoculated into these 2 species by intracerebral and oral routes. After intracerebral inoculation of squirrel monkeys, 7 of 8 CWD isolates induced a clinical wasting syndrome within 33–53 months. The monkeys’ brains showed spongiform encephalopathy and protease-resistant prion protein (PrPres) diagnostic of prion disease. After oral exposure, 2 squirrel monkeys had PrPres in brain, spleen, and lymph nodes at 69 months postinfection. In contrast, cynomolgus macaques have not shown evidence of clinical disease as of 70 months postinfection. Thus, these 2 species differed in susceptibility to CWD. Because humans are evolutionarily closer to macaques than to squirrel monkeys, they may also be resistant to CWD.
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影响因子：
--
作者：
Anderson, C. Alan;Bosque, Patrick;Tyler, Kenneth L.
通讯作者：
Tyler, Kenneth L.
影响因子：
5.4
作者：
KASCSAK, RJ;RUBENSTEIN, R;DIRINGER, H
通讯作者：
DIRINGER, H
影响因子：
0.8
作者：
Sigurdson, C. J.;Mathiason, C. K.;Hoover, E. A.
通讯作者：
Hoover, E. A.
影响因子：
3.7
作者：
Bartz, JC;Marsh, RF;Aiken, JM
通讯作者：
Aiken, JM
影响因子：
3.8
作者：
Harrington, Robert D.;Baszler, Timothy V.;Knowles, Donald P.
通讯作者：
Knowles, Donald P.