Role of oxytocin receptors in modulation of fear by social memory.
Role of oxytocin receptors in modulation of fear by social memory.
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DOI：
10.1007/s00213-013-3356-6
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发表时间：
2014-05
影响因子：
3.4
通讯作者：
Radulovic, Jelena
中科院分区：
文献类型：
--
作者：
Guzman, Yomayra F.;Tronson, Natalie C.;Sato, Keisuke;Mesic, Ivana;Guedea, Anita L.;Nishimori, Katsuhiko;Radulovic, Jelena
关键词：
催产素受体（Oxtr）是社会学习和情绪的重要介质，对恐惧和焦虑具有双向作用。与杏仁核中Oxtr的抗焦虑作用相反，我们最近发现，外侧隔中的Oxtr介导了小鼠社交失败引起的恐惧条件反射的增强。使用积极的社会互动，这损害了恐惧条件反射，在这里，我们试图描绘的作用隔Oxtr在恐惧调节依赖于社会记忆的效价。侧隔Oxtr的药理学和遗传学操作与恐惧范式的社会缓冲相结合，其中预先暴露于nonfearable同种减少随后的上下文恐惧条件反射，减少冻结行为所揭示的。拮抗和下调的Oxtr在侧隔取消，而催产素（Oxt）管理前预暴露于nonfearful同种促进减少冻结行为。中隔催产素系统增强了对社会交往的记忆，而不管它们的效价如何，减少了积极的社会交往后的恐惧，增强了消极的社会交往后的恐惧。这些发现至少部分解释了Oxt在恐惧调节中看似双向的作用。
Oxytocin receptors (Oxtr) are important mediators of social learning and emotion, with bidirectional effects on fear and anxiety. Contrary to the anxiolytic actions of Oxtr in the amygdala, we recently showed that Oxtr in the lateral septum mediate the enhancement of fear conditioning by social defeat in mice. Using positive social interactions, which impair fear conditioning, here we attempted to delineate whether the role septal Oxtr in fear regulation depends on the valence of the social memory. Pharmacological and genetic manipulations of lateral septal Oxtr were combined with the social buffering of fear paradigm, in which pre-exposure to nonfearful conspecifics reduces subsequent contextual fear conditioning, as revealed by decreased freezing behavior. Antagonism and down-regulation of Oxtr in the lateral septum abolished, while oxytocin (Oxt) administration before pre-exposure to nonfearful conspecifics facilitated the decrease of freezing behavior. The septal oxytocin system enhances memory of social interactions regardless of their valence, reducing fear after positive and enhancing fear after negative social encounters. These findings explain, at least in part, the seemingly bidirectional role of Oxt in fear regulation.
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影响因子：
25
作者：
Guzman, Yomayra F.;Tronson, Natalie C.;Jovasevic, Vladimir;Sato, Keisuke;Guedea, Anita L.;Mizukami, Hiroaki;Nishimori, Katsuhiko;Radulovic, Jelena
通讯作者：
Radulovic, Jelena
影响因子：
3.8
作者：
Calderazzo, L;Cavalheiro, EA;Bentivoglio, M
通讯作者：
Bentivoglio, M
影响因子：
3.3
作者：
BOSCARINO, JA
通讯作者：
BOSCARINO, JA
影响因子：
1.7
作者：
Endres, Thomas;Fendt, Markus
通讯作者：
Fendt, Markus
DOI：
10.1073/pnas.1012669107
发表时间：
2010-12-14
影响因子：
11.1
作者：
Bartz, Jennifer A.;Zaki, Jamil;Lydon, John E.
通讯作者：
Lydon, John E.