Ionic communication for implantable bioelectronics.
Ionic communication for implantable bioelectronics.
复制标题
植入式生物电子学的离子通信。
DOI:
10.1126/sciadv.abm7851
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发表时间:
2022-04-08
期刊:
影响因子:
13.6
通讯作者:
Khodagholy D
中科院分区:
文献类型:
--
作者:
Zhao Z;Spyropoulos GD;Cea C;Gelinas JN;Khodagholy D
Implanted bioelectronic devices require data transmission through tissue, but ionic conductivity and inhomogeneity of this medium complicate conventional communication approaches. Here, we introduce ionic communication (IC) that uses ions to effectively propagate megahertz-range signals. We demonstrate that IC operates by generating and sensing electrical potential energy within polarizable media. IC was tuned to transmit across a range of biologically relevant tissue depths. The radius of propagation was controlled to enable multiline parallel communication, and it did not interfere with concurrent use of other bioelectronics. We created a fully implantable IC-based neural interface device that acquired and noninvasively transmitted neurophysiologic data from freely moving rodents over a period of weeks with stability sufficient for isolation of action potentials from individual neurons. IC is a biologically based data communication that establishes long-term, high-fidelity interactions across intact tissue. Ionic communication is a biologically based in vivo data transmission method that uses ions to propagate megahertz signals.
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