Parity and breastfeeding are protective against breast cancer in Nigerian women.
Parity and breastfeeding are protective against breast cancer in Nigerian women.
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DOI：
10.1038/sj.bjc.6604275
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发表时间：
2008-03-11
影响因子：
8.8
通讯作者：
Olopade, O. I.
中科院分区：
文献类型：
--
作者：
Huo, D.;Adebamowo, C. A.;Ogundiran, T. O.;Akang, E. E.;Campbell, O.;Adenipekun, A.;Cummings, S.;Fackenthal, J.;Ademuyiwa, F.;Ahsan, H.;Olopade, O. I.
由于生殖因素与乳腺癌风险之间的关系尚未在撒哈拉以南非洲的土著妇女中进行系统研究，我们在尼日利亚进行了一项病例对照研究。在1998年至2006年期间，使用结构化问卷进行面对面访谈，收集819例乳腺癌病例和569例社区对照的详细生育史。采用Logistic回归估计比值比（OR）和95%置信区间（CI）。与初潮年龄<17岁的女性相比，初潮年龄> 17岁的女性的校正OR为0.72（95% CI：0.54-0.95，P=0.02）。产次与风险呈负相关（P趋势=0.02），但首次活产时的年龄不显著（P=0.16）。重要的是，母乳喂养每12个月，乳腺癌风险降低7%（P趋势=0.005）。值得注意的是，生育风险因素的分布从早出生队列到晚出生队列发生了显著变化，朝着乳腺癌发病率增加的方向发展。我们的研究结果还强调了不同人群乳腺癌病因的异质性，并表明需要在撒哈拉以南土著妇女中进行进一步研究。
As the relation between reproductive factors and breast cancer risk has not been systematically studied in indigenous women of sub-Saharan Africa, we examined this in a case–control study in Nigeria. In-person interviews were conducted using structured questionnaires to collect detailed reproductive history in 819 breast cancer cases and 569 community controls between 1998 and 2006. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CI). Compared with women with menarcheal age <17 years, the adjusted OR for women with menarcheal age ⩾17 years was 0.72 (95% CI: 0.54–0.95, P=0.02). Parity was negatively associated with risk (P-trend=0.02) but age at first live birth was not significant (P=0.16). Importantly, breast cancer risk decreased by 7% for every 12 months of breastfeeding (P-trend=0.005). It is worth noting that the distribution of reproductive risk factors changed significantly from early to late birth cohorts in the direction of increasing breast cancer incidence. Our findings also highlight the heterogeneity of breast cancer aetiology across populations, and indicate the need for further studies among indigenous sub-Saharan women.
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影响因子：
3.8
作者：
Chu, KC;Anderson, WF
通讯作者：
Anderson, WF
城市化尼日利亚妇女的腰围比和乳腺癌风险。
影响因子：
7.4
作者：
Adebamowo, CA;Ogundiran, TO;Adenipekun, AA;Oyesegun, RA;Campbell, OB;Akang, EE;Rotimi, CN;Olopade, OI
通讯作者：
Olopade, OI
影响因子：
3.8
作者：
Adebamowo, Clement A.;Famooto, Ayotunde;Akang, Effiong E.
通讯作者：
Akang, Effiong E.
影响因子：
5.6
作者：
Adebamowo, CA;Ogundiran, TO;Olopade, OI
通讯作者：
Olopade, OI
根据关节雌激素和孕激素受体状态的生殖因素和乳腺癌风险：流行病学研究的荟萃分析。
影响因子：
7.4
作者：
Ma, Huiyan;Bernstein, Leslie;Pike, Malcolm C.;Ursin, Giske
通讯作者：
Ursin, Giske