fMRI studies of reward processing in adolescent depression.
fMRI studies of reward processing in adolescent depression.
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DOI：
10.1038/npp.2010.164
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发表时间：
2011-01
期刊：
影响因子：
--
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中科院分区：
文献类型：
--
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奖励功能越来越被认为是抑郁症和双相情感障碍等情感障碍的一个重要方面。情感障碍的概念模型强调奖赏功能紊乱是抑郁症患者低积极情绪的神经特征，对成年人的研究表明，与奖赏相关区域的大脑功能将抑郁症患者与健康对照组区分开来。基于对青春期的兴趣，青春期既是情感性障碍发病的脆弱时期，也是神经奖赏回路持续发展的时期，一项新兴的文献现在正在研究患有抑郁症的青少年与奖赏相关的脑功能。功能神经成像研究结果表明，患有抑郁症的青少年(Forbes等人，2009)和有抑郁风险的青少年(例如Gotlib等人，2010)对奖励刺激(如金钱或快乐的面部表情)表现出低纹状体反应。在对奖励的预期和接受奖励的过程中，观察到了这种大脑功能的变化，这表明青少年抑郁症涉及到获得奖励的动机和获得奖励后的享受两者的变化。
Reward function is increasingly considered to be an important aspect of affective disorders such as depression and bipolar disorder. Conceptual models of affective disorders emphasize disrupted reward function as a neural characteristic of low positive affect in depression, and studies with adults have indicated that brain function in reward-related regions distinguishes those with depression from healthy controls. Based on an interest in adolescence, as both a vulnerable period for the onset of affective disorders and a period of ongoing development of neural reward circuitry, an emerging literature is now addressing reward-related brain function in adolescents with depression. Results have generally paralleled those from adult studies and have indicated value in studying reward function in relation to the etiology, pathophysiology, and treatment of depression in young people.Functional neuroimaging findings indicate that adolescents with depression (Forbes et al, 2009) and adolescents at risk for depression (eg, Gotlib et al, 2010) exhibit low striatal response to rewarding stimuli, such as money or happy facial expressions. This altered brain function has been observed during the anticipation of reward and the receipt of reward, suggesting that adolescent depression involves changes in both the motivation to obtain reward and the enjoyment of rewards once obtained.
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DOI：
10.1176/appi.ajp.2008.07081336
发表时间：
2009-01
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Forbes EE;Hariri AR;Martin SL;Silk JS;Moyles DL;Fisher PM;Brown SM;Ryan ND;Birmaher B;Axelson DA;Dahl RE
通讯作者：
Dahl RE
DOI：
10.1016/j.jaac.2009.11.006
发表时间：
2010-02-01
影响因子：
13.3
作者：
Forbes, Erika E.;Ryan, Neal D.;Dahl, Ronald E.
通讯作者：
Dahl, Ronald E.
DOI：
10.3758/cabn.10.1.107
发表时间：
2010-03
期刊：
Cognitive, affective & behavioral neuroscience
影响因子：
--
作者：
Forbes EE;Olino TM;Ryan ND;Birmaher B;Axelson D;Moyles DL;Dahl RE
通讯作者：
Dahl RE
影响因子：
--
作者：
Gotlib, Ian H.;Hamilton, J. Paul;Cooney, Rebecca E.;Singh, Manpreet K.;Henry, Melissa L.;Joormann, Jutta
通讯作者：
Joormann, Jutta