Neural processing of reward and loss in girls at risk for major depression.
Neural processing of reward and loss in girls at risk for major depression.
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DOI：
10.1001/archgenpsychiatry.2010.13
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发表时间：
2010-04
影响因子：
--
通讯作者：
Joormann, Jutta
中科院分区：
文献类型：
--
作者：
Gotlib, Ian H.;Hamilton, J. Paul;Cooney, Rebecca E.;Singh, Manpreet K.;Henry, Melissa L.;Joormann, Jutta
奖励处理的缺陷及其神经相关性与重度抑郁症有关。然而，目前尚不清楚这些缺陷是在抑郁症发作之前还是这种疾病的后果。确定奖励的异常神经处理是否是缺乏个人精神病理学史的抑郁症家族风险儿童的特征。比较抑郁症低风险和高风险儿童在处理奖励和损失时的神经活动。大学功能磁共振成像设备。13名10- 14岁的女儿从未患过抑郁症，母亲患有复发性抑郁症（“高风险”），13名年龄匹配的女儿从未患过抑郁症，没有抑郁症家族史（“低风险”）。在预期和接受奖励和损失的过程中，用功能磁共振成像测量关键奖励和注意神经回路的神经活动。在预期收益的同时，高风险参与者的壳核和左丘脑的激活程度低于低风险参与者，但右丘脑的激活程度高于低风险参与者。当接受惩罚时，高风险参与者的背侧前扣带回比低风险参与者表现出更大的激活，后者在尾状核和壳核表现出更大的激活。抑郁症的家族风险影响奖励和损失处理的神经机制;年轻女孩在抑郁症发作前表现出异常的奖励和损失处理。需要进行纵向研究来检验这些特征是否能预测随后的抑郁症发作。
Deficits in reward processing and their neural correlates have been associated with major depression. It is unclear, however, if these deficits precede the onset of depression or are a consequence of this disorder. To determine whether anomalous neural processing of reward characterizes children at familial risk for depression in the absence of a personal history of psychopathology. Comparing neural activity of children at low and high risk for depression as they process reward and loss. University fMRI facility. Thirteen 10– 14-year-old never-disordered daughters of mothers with recurrent depression (“high risk”) and 13 age-matched never-disordered daughters with no family history of depression (“low risk”). Neural activity, as measured with fMRI, in key reward and attention neural circuitry during anticipation and receipt of reward and loss. While anticipating gains, high-risk participants showed less activation than did their low-risk counterparts in the putamen and left insula, but greater activation in the right insula. When receiving punishment, high-risk participants showed greater activation in the dorsal anterior cingulate gyrus than did low-risk participants, who showed greater activation in the caudate and putamen. Familial risk for depression affects neural mechanisms underlying the processing of reward and loss; young girls at risk for depression exhibit anomalies in the processing of reward and loss prior to the onset of depressive symptoms. Longitudinal studies are needed to examine whether these characteristics predict the subsequent onset of depression.
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