The neural basis of predicting the outcomes of imagined actions.
The neural basis of predicting the outcomes of imagined actions.
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DOI：
10.3389/fnins.2011.00128
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发表时间：
2011
影响因子：
4.3
通讯作者：
Brown JW
中科院分区：
文献类型：
--
作者：
Jahn A;Nee DE;Brown JW
人类智能的一个关键特征是能够在执行之前预测自己行为的结果。行动价值被认为是在背侧和腹侧内侧前额叶皮层（mPFC）的一部分，但目前的研究集中在执行的行动，而不是一个计划的行动的预期价值的价值。因此，人们对个体如何思考（或无法思考）他们的行为以及他们行动前的潜在后果的神经基础知之甚少。我们用功能磁共振成像扫描个体，同时他们考虑执行他们知道可能会得到奖励或没有奖励的行为。在这里，我们表明，仅仅想象一个没有得到奖励的行动，而不是想象一个得到奖励的行动，增加了背侧前扣带皮层的活动，独立于随后的行动。这种活动与对实际无回报行为做出反应的区域重叠。研究结果显示了一个独特的网络，它标志着一个人可能采取的行动的预期结果。许多临床疾病，如精神分裂症和药物滥用，都涉及在采取行动之前未能考虑到行动的潜在后果。因此，我们的研究结果表明，mPFC的功能障碍可能有助于这种失败。
A key feature of human intelligence is the ability to predict the outcomes of one’s own actions prior to executing them. Action values are thought to be represented in part in the dorsal and ventral medial prefrontal cortex (mPFC), yet current studies have focused on the value of executed actions rather than the anticipated value of a planned action. Thus, little is known about the neural basis of how individuals think (or fail to think) about their actions and the potential consequences before they act. We scanned individuals with fMRI while they thought about performing actions that they knew would likely be rewarded or unrewarded. Here we show that merely imagining an unrewarded action, as opposed to imagining a rewarded action, increases activity in the dorsal anterior cingulate cortex, independently of subsequent actions. This activity overlaps with regions that respond to actual unrewarded actions. The findings show a distinct network that signals the prospective outcomes of one’s possible actions. A number of clinical disorders such as schizophrenia and drug abuse involve a failure to take the potential consequences of an action into account prior to acting. Our results thus suggest how dysfunctions of the mPFC may contribute to such failures.
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