The state of the art in breast imaging using the Twente Photoacoustic Mammoscope: results from 31 measurements on malignancies.
The state of the art in breast imaging using the Twente Photoacoustic Mammoscope: results from 31 measurements on malignancies.
复制标题
DOI：
10.1007/s00330-016-4240-7
复制
发表时间：
2016-11
影响因子：
5.9
通讯作者：
Manohar, Srirang
中科院分区：
文献类型：
--
作者：
Heijblom, Michelle;Piras, Daniele;van den Engh, Frank M.;van der Schaaf, Margreet;Klaase, Joost M.;Steenbergen, Wiendelt;Manohar, Srirang
光声乳腺摄影是一种潜在的理想技术，然而，患者数据量有限。为了进一步了解该方法的体内性能并指导进一步的研究和开发，我们使用研究系统Twente光声乳腺镜（PAM）对33例乳腺恶性肿瘤进行了成像。31例患者参加了这项回顾性观察性研究。研究和知情同意程序得到了当地伦理委员会的批准。PAM使用1，064 nm的光进行激发，并使用平面的588元件1 MHz超声阵列进行检测。将光声损伤可见性和外观与常规成像（X射线乳腺摄影和超声检查）结果、组织病理学和患者人口统计学进行比较。在33个恶性肿瘤中，32个显示为高对比度，与常规成像具有良好的共定位。检测到的恶性肿瘤的对比度与放射学乳腺密度无关，大小估计合理，与组织学平均偏差为28%。然而，恶性肿瘤区域外存在造影剂区域提示当前系统的低特异性。统计分析未显示PAM结果与患者人口统计学或病变特征之间的任何进一步关系。结果证实了光声乳腺摄影在未来乳腺护理中的高潜力。 ·光声乳腺成像以高成像对比度可视化恶性肿瘤。 ·光声病变对比度独立于乳房摄影估计的乳房密度。 ·光声特性与病变类型、级别等之间不存在明确的关系。 ·来自某些情况的对乳腺癌的光声特异性还不是最佳的。
Photoacoustic mammography is potentially an ideal technique, however, the amount of patient data is limited. To further our understanding of the in vivo performance of the method and to guide further research and development, we imaged 33 breast malignancies using the research system – the Twente Photoacoustic Mammoscope (PAM). Thirty-one patients participated in this retrospective, observational study. The study and informed consent procedure were approved by the local ethics committee. PAM uses 1,064 nm light for excitation with a planar, 588-element, 1-MHz ultrasound array for detection. Photoacoustic lesion visibility and appearance were compared with conventional imaging (x-ray mammography and ultrasonography) findings, histopathology and patient demographics. Of 33 malignancies 32 were visualized with high contrast and good co-localization with conventional imaging. The contrast of the detected malignancies was independent of radiographic breast density, and size estimation was reasonably good with an average 28 % deviation from histology. However, the presence of contrast areas outside the malignant region is suggestive for low specificity of the current system. Statistical analyses did not reveal any further relationship between PAM results and patient demographics nor lesion characteristics. The results confirm the high potential of photoacoustic mammography in future breast care. • Photoacoustic breast imaging visualizes malignancies with high imaging contrast. • Photoacoustic lesion contrast is independent of the mammographically estimated breast density. • No clear relationship exists between photoacoustic characteristics and lesion type, grade, etc. • Photoacoustic specificity to breast cancer from some cases is not yet optimal.
登录
查看更多内容
影响因子：
3.5
作者：
Ermilov, Sergey A.;Khamapirad, Tuenchit;Oraevsky, Alexander A.
通讯作者：
Oraevsky, Alexander A.
影响因子：
3.5
作者：
Cerussi, Albert;Shah, Natasha;Tromberg, Bruce J.
通讯作者：
Tromberg, Bruce J.
影响因子：
19.7
作者：
Jochelson, Maxine S.;Dershaw, D. David;Morris, Elizabeth A.
通讯作者：
Morris, Elizabeth A.
超越乳腺X线摄影：乳腺癌筛查的新领域。
影响因子：
5.9
作者：
Drukteinis, Jennifer S.;Mooney, Blaise P.;Flowers, Chris I.;Gatenby, Robert A.
通讯作者：
Gatenby, Robert A.
影响因子：
3.4
作者：
Carp, Stefan A.;Sajjadi, Amir Y.;Isakoff, Steven J.
通讯作者：
Isakoff, Steven J.