The mouse genome database (MGD): new features facilitating a model system.
The mouse genome database (MGD): new features facilitating a model system.
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DOI：
10.1093/nar/gkl940
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发表时间：
2007-01
影响因子：
14.9
通讯作者：
Mouse Genome Database Group
中科院分区：
文献类型：
--
作者：
Eppig JT;Blake JA;Bult CJ;Kadin JA;Richardson JE;Mouse Genome Database Group
小鼠基因组数据库 (MGD, ) 是国际小鼠社区数据库，提供有关实验室小鼠遗传学、基因组学和生物学的广泛综合数据。小鼠是研究人类正常发育和疾病过程的优秀而独特的动物替代品。因此，MGD 的主要目标是促进使用小鼠模型来研究人类疾病，并促进基于比较基因型、表型和功能分析的转化研究假设的发展。 MGD核心数据内容包括基因特征和功能、表型和疾病模型描述、DNA和蛋白质序列数据、多态性、基因作图数据和基因组坐标，以及针对哺乳动物的比较基因数据。使用自动化流程和专家人工管理相结合，整合来自不同来源的数据，从主要资源中心到个体研究人员实验室和科学文献。 MGD 与生物信息学界合作开发数据和语义标准，并将关键本体纳入 MGD 注释系统，包括基因本体 (GO)、哺乳动物表型本体以及小鼠发育和成人解剖学解剖词典。 MGD 是小鼠基因、等位基因和小鼠品系命名法以及小鼠基因 GO 注释的权威来源。 MGD 为数据挖掘和假设生成提供了一个独特的平台，可以在其中同时表达复杂的查询，解决表型效应、生化功能和过程、亚细胞位置、表达、序列、多态性和映射数据。提供基于网络的查询和对数据的计算访问。这里描述的 MGD 的最新改进包括合并单核苷酸多态性数据和搜索工具、添加 PIR 基因超家族分类、NIH 获得的基因敲除小鼠的表型数据、小鼠表型基因型的图像、GO 注释的新功能图显示以及包括序列信息和图形显示的新直系同源显示。
The mouse genome database (MGD, ), the international community database for mouse, provides access to extensive integrated data on the genetics, genomics and biology of the laboratory mouse. The mouse is an excellent and unique animal surrogate for studying normal development and disease processes in humans. Thus, MGD's primary goals are to facilitate the use of mouse models for studying human disease and enable the development of translational research hypotheses based on comparative genotype, phenotype and functional analyses. Core MGD data content includes gene characterization and functions, phenotype and disease model descriptions, DNA and protein sequence data, polymorphisms, gene mapping data and genome coordinates, and comparative gene data focused on mammals. Data are integrated from diverse sources, ranging from major resource centers to individual investigator laboratories and the scientific literature, using a combination of automated processes and expert human curation. MGD collaborates with the bioinformatics community on the development of data and semantic standards, and it incorporates key ontologies into the MGD annotation system, including the Gene Ontology (GO), the Mammalian Phenotype Ontology, and the Anatomical Dictionary for Mouse Development and the Adult Anatomy. MGD is the authoritative source for mouse nomenclature for genes, alleles, and mouse strains, and for GO annotations to mouse genes. MGD provides a unique platform for data mining and hypothesis generation where one can express complex queries simultaneously addressing phenotypic effects, biochemical function and process, sub-cellular location, expression, sequence, polymorphism and mapping data. Both web-based querying and computational access to data are provided. Recent improvements in MGD described here include the incorporation of single nucleotide polymorphism data and search tools, the addition of PIR gene superfamily classifications, phenotype data for NIH-acquired knockout mice, images for mouse phenotypic genotypes, new functional graph displays of GO annotations, and new orthology displays including sequence information and graphic displays.
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影响因子：
6.5
作者：
Hunt, MC;Yamada, J;Alexson, SEH
通讯作者：
Alexson, SEH
影响因子：
14.9
作者：
Blake JA;Eppig JT;Bult CJ;Kadin JA;Richardson JE;Mouse Genome Database Group
通讯作者：
Mouse Genome Database Group
2006年的基因本体论（GO）项目。
影响因子：
14.9
作者：
Harris, Midori A.;Clark, Jennifer I.;Ireland, Amelia;Lomax, Jane;Ashburner, Michael;Collins, Russell;Eilbeck, Karen;Lewis, Suzanna;Mungall, Chris;Richter, John;Rubin, Gerald M.;Shu, ShengQiang;Blake, Judith A.;Bult, Carol J.;Diehl, Alexander D.;Dolan, Mary E.;Drabkin, Harold J.;Eppig, Janan T.;Hill, David P.;Ni, Li;Ringwald, Martin;Balakrishnan, Rama;Binkley, Gail;Cherry, J. Michael;Christie, Karen R.;Costanzo, Maria C.;Dong, Qing;Engel, Stacia R.;Fisk, Dianna G.;Hirschman, Jodi E.;Hitz, Benjamin C.;Hong, Eurie L.;Lane, Christopher;Miyasato, Stuart;Nash, Robert;Sethuraman, Anand;Skrzypek, Marek;Theesfeld, Chandra L.;Weng, Shuai;Botstein, David;Dolinski, Kara;Oughtred, Rose;Berardini, Tanya;Mundodi, Suparna;Rhee, Seung Y.;Apweiler, Rolf;Barrell, Daniel;Camon, Evelyn;Dimmer, Emily;Mulder, Nicola;Chisholm, Rex;Fey, Petra;Gaudet, Pascale;Kibbe, Warren;Pilcher, Karen;Bastiani, Carol A.;Kishore, Ranjana;Schwarz, Erich M.;Sternberg, Paul;Van Auken, Kimberly;Gwinn, Michelle;Hannick, Linda;Wortman, Jennifer;Aslett, Martin;Berriman, Matthew;Wood, Valerie;Bromberg, Susan;Foote, Cindy;Jacob, Howard;Pasko, Dean;Petri, Victoria;Reilly, Dorothy;Seiler, Kathy;Shimoyama, Mary;Smith, Jennifer;Twigger, Simon;Jaiswal, Pankaj;Seigfried, Trent;Collmer, Candace;Howe, Doug;Westerfield, Monte
通讯作者：
Westerfield, Monte
影响因子：
1.7
作者：
Krupke, DM;N채f, D;Eppig, JT
通讯作者：
Eppig, JT
影响因子：
1.5
作者：
Strivens, M;Eppig, JT
通讯作者：
Eppig, JT