Comparing Brain Morphometry Across Multiple Childhood Psychiatric Disorders.
Comparing Brain Morphometry Across Multiple Childhood Psychiatric Disorders.
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DOI：
10.1016/j.jaac.2016.08.008
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发表时间：
2016-12
影响因子：
13.3
通讯作者：
Leibenluft, Ellen
中科院分区：
文献类型：
--
作者：
Gold, Andrea L.;Brotman, Melissa A.;Adleman, Nancy E.;Lever, Sara N.;Steuber, Elizabeth R.;Fromm, Stephen J.;Mueller, Sven C.;Pine, Daniel S.;Leibenluft, Ellen
关键词：
在儿童和成人中，精神疾病与大脑结构的改变有关，特别是在前额叶皮层（PFC）。然而，大多数研究比较了健康志愿者（HV）和精神病组的灰质体积（GMV）。我们比较了患有焦虑症、双相情感障碍（BD）、破坏性情绪失调症（DMDD）、注意力缺陷多动障碍（ADHD）和HV的青少年的GMV。3-对184名青少年（39名焦虑、20名BD、52名DMDD、20名ADHD和53名HV）进行特斯拉T1加权磁共振成像（MRI）扫描。进行基于体素的形态测定分析。单因素方差分析（ANOVA）测试GMV差异，全脑家族误差（FWE; p<.05）校正;二级探索性全脑分析使用p<.001的阈值，≥200体素。鉴于最近的框架倡导维度的方法在精神病理学研究中，我们还测试了GMV与持续焦虑，易怒和注意力不集中症状的关联。特异性出现在左背外侧PFC（dlPFC），这与BD，焦虑，和HV青年之间的差异; GMV在青年焦虑增加，但在BD下降，相对于HV。二次分析显示BD特异性GMV在右侧PFC、右侧dlPFC和背内侧PFC中降低，并且焦虑特异性GMV在左侧dlPFC、右侧腹外侧PFC、额极和右侧海马旁回/舌回中增加。BD和DMDD均显示右侧dlPFC/上级额回GMV相对于HV降低。GMV与焦虑、易怒或ADHD症状的维度测量无关。这两种疾病的具体和共享的GMV差异表现在儿科精神病理学。一些差异是特定于焦虑症，其他特定于BD，以及其他BD和DMDD之间共享。进一步的发展研究可能会映射不同的儿科精神病理学的结构和功能的共性和差异。
In both children and adults, psychiatric illness is associated with structural brain alterations, particularly in the prefrontal cortex (PFC). However, most studies compare gray matter volume (GMV) in healthy volunteers (HVs) to one psychiatric group. We compared GMV among youth with anxiety disorders, bipolar disorder (BD), disruptive mood dysregulation disorder (DMDD), attention-deficit/hyperactivity disorder (ADHD), and HVs. 3-Tesla T1-weighted magnetic resonance imaging (MRI) scans were acquired in 184 youths (39 anxious, 20 BD, 52 DMDD, 20 ADHD, and 53 HV). Voxel-based morphometry analyses were conducted. One-way analysis of variance (ANOVA) tested GMV differences with whole-brain family-wise error (FWE; p<.05) correction; secondary, exploratory whole-brain analyses used a threshold of p<.001, ≥200 voxels. Given recent frameworks advocating for dimensional approaches in psychopathology research, we also tested GMV associations with continuous anxiety, irritability, and inattention symptoms. Specificity emerged in left dorsolateral PFC (dlPFC), which differed among youth with BD, anxiety, and HVs; GMV was increased in youth with anxiety, but decreased in BD, relative to HVs. Secondary analyses revealed BD-specific GMV decreases in right lateral PFC, right dlPFC, and dorsomedial PFC, and also anxiety-specific GMV increases in left dlPFC, right ventrolateral PFC, frontal pole, and right parahippocampal gyrus/lingual gyrus. Both BD and DMDD showed decreased GMV relative to HVs in right dlPFC/superior frontal gyrus. GMV was not associated with dimensional measures of anxiety, irritability, or ADHD symptoms. Both disorder-specific and shared GMV differences manifest in pediatric psychopathology. Some differences were specific to anxiety disorders, others specific to BD, and others shared between BD and DMDD. Further developmental research might map commonalities and differences of structure and function in diverse pediatric psychopathologies.
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影响因子：
16.2
作者：
Giedd, Jay N.;Rapoport, Judith L.
通讯作者：
Rapoport, Judith L.
影响因子：
3.7
作者：
Ducharme, Simon;Albaugh, Matthew D.;Karama, Sherif
通讯作者：
Karama, Sherif
DOI：
10.1176/appi.ajp.2009.09010043
发表时间：
2010-01
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Brotman MA;Rich BA;Guyer AE;Lunsford JR;Horsey SE;Reising MM;Thomas LA;Fromm SJ;Towbin K;Pine DS;Leibenluft E
通讯作者：
Leibenluft E
影响因子：
4.5
作者：
Ellison-Wright, Ian;Bullmore, Edward T.
通讯作者：
Bullmore, Edward T.
影响因子：
--
作者：
Dickstein, DP;Milham, MP;Leibenluft, E
通讯作者：
Leibenluft, E