An NIR photothermal-responsive hybrid hydrogel for enhanced wound healing.
An NIR photothermal-responsive hybrid hydrogel for enhanced wound healing.
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DOI：
10.1016/j.bioactmat.2022.03.006
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发表时间：
2022-10
影响因子：
18.9
通讯作者：
Jiang X
中科院分区：
文献类型：
--
作者：
Jin L;Guo X;Gao D;Liu Y;Ni J;Zhang Z;Huang Y;Xu G;Yang Z;Zhang X;Jiang X
适度调节创面血管化和免疫微环境是实现皮肤无瘢痕愈合的必要条件。本文中，我们制备了具有核-壳结构的促进血管生成和防止疤痕的创可贴，其由作为核的MXene负载的纳米纤维（MNF）和作为壳的多巴胺-透明质酸水凝胶（H）（MNF @V-H@DA）组成，以包封生长因子（血管内皮生长因子，VEGF，缩写为V）和H2S供体（二烯丙基三硫化物，DATS，缩写为DA）。DA从该系统的持续释放产生H2S，其将成功地诱导巨噬细胞转化为M2-lile表型，调节免疫微环境并抑制伤口部位的过度炎症反应。它有利于皮肤细胞的增殖，促进伤口愈合。此外，通过调整近红外（NIR）光暴露的时间，可以从MXene纳米纤维骨架中释放适量的VEGF，防止伤口部位过度的新血管形成和细胞外基质沉积。总的来说，这种NIR光热响应创可贴通过梯度控制的血管化和受损皮肤组织的相关免疫顺序反应实现了无瘢痕伤口愈合。制备了一种以MXene纳米纤维（MNF）为芯、多巴胺-羟基磷灰石水凝胶（H）为壳的促进血管新生和防止瘢痕形成的创可贴（MNF @V-H@DA）。这种NIR光热响应创可贴通过梯度控制的血管化和受损皮肤组织的相关免疫顺序反应实现了无瘢痕伤口愈合，这是实现无瘢痕伤口愈合的有希望的策略。水凝胶和纳米纤维的混合系统被开发为伤口愈合的创可贴。光热疗法诱导的轻度热疗可实现VEGF的控制释放，以促进创面适当的新生血管形成。H2S的持续释放促进了巨噬细胞向M2样表型极化，从而调节伤口部位的免疫微环境。新生血管和免疫调节的协同作用加速了伤口愈合。
Moderately regulating vascularization and immune microenvironment of wound site is necessary to achieve scarless wound healing of the skin. Herein, we have prepared an angiogenesis-promoting and scar-preventing band-aid with a core-shell structure, that consists of MXene-loaded nanofibers (MNFs) as the core and dopamine-hyaluronic acid hydrogel (H) as the shell (MNFs@V–H@DA) to encapsulate a growth factor (vascular endothelial growth factor, VEGF, abbreviated as V) and H2S donor (diallyl trisulfide, DATS, abbreviated as DA). The continuous release of DA from this system produced H2S, which would successfully induce macrophages to polarize into M2-lile phenotype, regulating the immune microenvironment and inhibiting an excessive inflammatory response at the wound sites. It is conducive to the proliferation of skin cells, facilitating the wound healing. In addition, an appropriate amount of VEGF can be released from the MXene nanofibrous skeleton by adjusting the time of near-infrared (NIR) light exposure, preventing excessive neovascularization and extracellular matrix deposition at the wound sites. Collectively, this NIR photothermal-responsive band-aid achieved scarless wound healing through gradient-controlled vascularization and a related immune sequential reaction of damaged skin tissue. An angiogenesis-promoting and scar-preventing band-aid that consists of MXene-loaed nanofibers (MNFs) as the core and dopamine-hydroxyapatite hydrogel (H) as the shell (MNFs@V–H@DA) was prepared. This NIR photothermal-responsive band-aid achieved scarless wound healing through gradient-controlled vascularization and a related immune sequential reaction of damaged skin tissue, which is a promising strategy to achieve scarless wound healing. A hybrid system combining hydrogel and nanofibers developed as band-aid for wound healing. Mild hyperthermia induced by photothermal therapy achieves VEGF controlled release for appropriate neovascularization of wound site. Continuous release of H2S facilitates the polarization of macrophages toward M2-like phenotype to regulate immune microenvironment of wound site. The synergism of neovascularization and immune regulation accelerates the wound healing.
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影响因子：
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