Anterior prefrontal hemodynamic connectivity in conscious 3- to 7-year-old children with typical development and autism spectrum disorder.
Anterior prefrontal hemodynamic connectivity in conscious 3- to 7-year-old children with typical development and autism spectrum disorder.
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DOI：
10.1371/journal.pone.0056087
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Minabe Y
中科院分区：
文献类型：
--
作者：
Kikuchi M;Yoshimura Y;Shitamichi K;Ueno S;Hiraishi H;Munesue T;Hirosawa T;Ono Y;Tsubokawa T;Inoue Y;Oi M;Niida Y;Remijn GB;Takahashi T;Suzuki M;Higashida H;Minabe Y
社会交际障碍是自闭症谱系障碍（ASD）的显著特征。前额叶前部皮层（aPFC），或称Brodmann区10，是社会功能的关键处理区域，该区域的非典型发育被认为在ASD的社会缺陷中起作用。了解自闭症儿童的这些大脑功能是很重要的。然而，这些大脑功能还没有很好地描述在年幼的自闭症儿童有意识的情况下。在本研究中，我们重点研究了ASD儿童和典型发育（TD）儿童左右aPFC之间的脑血流动力学功能连通性，并探讨了这种连通性与社交能力之间是否存在相关性。采用近红外光谱（NIRS）无创测量了3- 7岁ASD儿童（n = 15）和性别和年龄匹配的TD儿童（n = 15）的脑血流动力学波动。通过测量解说图片卡表演过程中低频自发波动（0.01 ~ 0.10 Hz）的相干性来评估左右aPFC之间的功能连通性。一致性分析表明，ASD儿童在0.02 Hz波动时具有显著更高的半球间连通性，而功率分析并未显示两组之间在低频波动（0.01 - 0.10 Hz）方面存在显著差异。自闭症诊断观察表（Autism Diagnostic Observation Schedule）的评分显示，自闭症儿童的这种异常的高连通性与社交缺陷的严重程度呈正相关。这是第一个证明患有ASD的幼儿在意识状态下左右aPFC之间异常的脑功能连接的研究。
Socio-communicative impairments are salient features of autism spectrum disorder (ASD) from a young age. The anterior prefrontal cortex (aPFC), or Brodmann area 10, is a key processing area for social function, and atypical development of this area is thought to play a role in the social deficits in ASD. It is important to understand these brain functions in developing children with ASD. However, these brain functions have not yet been well described under conscious conditions in young children with ASD. In the present study, we focused on the brain hemodynamic functional connectivity between the right and the left aPFC in children with ASD and typically developing (TD) children and investigated whether there was a correlation between this connectivity and social ability. Brain hemodynamic fluctuations were measured non-invasively by near-infrared spectroscopy (NIRS) in 3- to 7-year-old children with ASD (n = 15) and gender- and age-matched TD children (n = 15). The functional connectivity between the right and the left aPFC was assessed by measuring the coherence for low-frequency spontaneous fluctuations (0.01 – 0.10 Hz) during a narrated picture-card show. Coherence analysis demonstrated that children with ASD had a significantly higher inter-hemispheric connectivity with 0.02-Hz fluctuations, whereas a power analysis did not demonstrate significant differences between the two groups in terms of low frequency fluctuations (0.01 – 0.10 Hz). This aberrant higher connectivity in children with ASD was positively correlated with the severity of social deficit, as scored with the Autism Diagnostic Observation Schedule. This is the first study to demonstrate aberrant brain functional connectivity between the right and the left aPFC under conscious conditions in young children with ASD.
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影响因子：
14.5
作者：
Just, MA;Cherkassky, VL;Minshew, NJ
通讯作者：
Minshew, NJ
影响因子：
1.7
作者：
Kikuchi, Mitsuru;Shitamichi, Kiyomi;Minabe, Yoshio
通讯作者：
Minabe, Yoshio
影响因子：
5.7
作者：
Alexander, Andrew L.;Lee, Jee Eun;Lainhart, Janet E.
通讯作者：
Lainhart, Janet E.
影响因子：
2.6
作者：
Burgess, Paul W.;Gonen-Yaacovi, Gil;Volle, Emmanuelle
通讯作者：
Volle, Emmanuelle
影响因子：
5.3
作者：
Belmonte, MK;Allen, G;Webb, SJ
通讯作者：
Webb, SJ