The association between physical activity and bladder cancer: systematic review and meta-analysis.
The association between physical activity and bladder cancer: systematic review and meta-analysis.
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DOI：
10.1038/bjc.2014.77
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发表时间：
2014-04-02
影响因子：
8.8
通讯作者：
Leitzmann, M. F.
中科院分区：
文献类型：
--
作者：
Keimling, M.;Behrens, G.;Schmid, D.;Jochem, C.;Leitzmann, M. F.
体育锻炼可能通过几种生物途径来预防膀胱癌，例如增强免疫功能和减少慢性炎症。体育锻炼还可能通过减少肥胖间接预防膀胱癌。大量的流行病学研究已经检验了体力活动和膀胱癌之间的联系，但现有的证据还没有用荟萃分析进行正式总结。我们对1975年1月至2013年11月发表的英语研究进行了系统的文献回顾和荟萃分析。我们遵循Prisma指南，并使用随机效应模型来估计体力活动与膀胱癌之间的关联的总体风险估计。共纳入15项研究，包括5例 402例 369例和27例 784例膀胱癌患者。高水平和低水平的体力活动与降低膀胱癌风险有关(汇总相对风险(RR)=0.8595%可信区间(CI)=0.74-0.98；在所有研究中，I2=83%P值-异质性<；0.001)。队列研究(RR=0.89，95%CI=0.80~1.00；I2=%)和病例对照研究(RR=0.71，95%CI=0.43~1.16；I2=87%P值=0.108)相似，女性(RR=0.83，95%CI=0.73~0.94；I2=0%)和男性(RR=0.92，95%CI=0.82~1.05；I2=67；差异P值=0.657)具有可比性。娱乐活动(RR=0.81，95%CI=0.66~0.99；I2=77%)和职业性体力活动(RR=0.90，95%CI=0.76~1.0；I2=76%P值=0.374)，中度(RR=0.85，95%CI=0.75~0.98；I2=76%)和剧烈活动(RR=0.80，95%CI=0.64~1.00；I2=87%P值=0.535)基本一致。体力活动与降低患膀胱癌的风险有关。需要进一步的研究来评估生活中体力活动的强度、频率、持续时间和时间与膀胱癌风险的关系。
Physical activity may protect against bladder cancer through several biologic pathways, such as enhanced immune function and decreased chronic inflammation. Physical activity may also indirectly prevent bladder cancer by reducing obesity. A sizeable number of epidemiologic studies have examined the association between physical activity and bladder cancer, but the available evidence has not yet been formally summarised using meta-analysis. We performed a systematic literature review and meta-analysis of English-language studies published from January 1975 through November 2013. We followed the PRISMA guidelines and used a random effects model to estimate the summary risk estimates for the association between physical activity and bladder cancer. A total of 15 studies with 5 402 369 subjects and 27 784 bladder cancer cases were included. High vs low levels of physical activity were related to decreased bladder cancer risk (summary relative risk (RR)=0.85, 95% confidence interval (CI)=0.74–0.98; I2=83% P-value for heterogeneity across all studies<0.001). Results were similar for cohort studies (RR=0.89, 95% CI=0.80–1.00; I2=64%) and case–control studies (RR=0.71, 95% CI=0.43–1.16; I2=87% P-value for difference=0.108) and they were comparable for women (RR=0.83, 95% CI=0.73–0.94; I2=0%) and men (RR=0.92, 95% CI=0.82–1.05; I2=67; P-value for difference=0.657). Findings were also comparable for recreational (RR=0.81, 95% CI=0.66–0.99; I2=77%) and occupational physical activity (RR=0.90, 95% CI=0.76–1.0; I2=76% P-value for difference=0.374), and they were largely consistent for moderate (RR=0.85, 95% CI=0.75–0.98; I2=76%) and vigorous activity (RR=0.80, 95% CI=0.64–1.00;I2=87% P-value for difference=0.535). Physical activity is associated with decreased risk of bladder cancer. Further studies are required to assess the relations of intensity, frequency, duration, and timing in life of physical activity to bladder cancer risk.
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影响因子：
120.7
作者：
Jüni, P;Witschi, A;Egger, M
通讯作者：
Egger, M
影响因子：
2.6
作者：
Parent, Marie-Elise;Rousseau, Marie-Claude;Siemiatycki, Jack
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Siemiatycki, Jack
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2.5
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Sarna, S
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作者：
Hemelt, Marjolein;Yamamoto, Hidekazu;Zeegers, Maurice P. A.
通讯作者：
Zeegers, Maurice P. A.
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5.4
作者：
Fang, Hong;Yao, Baodong;Zhao, Yanping
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Zhao, Yanping