Muscle mass decline, arterial stiffness, white matter hyperintensity, and cognitive impairment: Japan Shimanami Health Promoting Program study.
Muscle mass decline, arterial stiffness, white matter hyperintensity, and cognitive impairment: Japan Shimanami Health Promoting Program study.
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肌肉质量下降，动脉僵硬，白质超强度和认知障碍：日本Shimanami健康促进计划研究。
DOI：
10.1002/jcsm.12195
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发表时间：
2017-08
期刊：
影响因子：
--
通讯作者：
Igase M
中科院分区：
文献类型：
--
作者：
Kohara K;Okada Y;Ochi M;Ohara M;Nagai T;Tabara Y;Igase M
虚弱和认知障碍之间有着密切的联系。然而，肌肉减少症对认知障碍发展的潜在贡献尚不清楚。我们在一项针对1518名55岁或以上受试者的横断面研究中调查了肌肉质量下降与认知障碍之间的可能关联。我们还评估了动脉硬化和白色高信号（WMH）作为这种关联的可能潜在机制。测量两个肌肉减少指数：大腿肌肉横截面积（CSA;通过计算机断层扫描计算）和骨骼肌质量（生物电阻抗）。肌肉质量下降被定义为每种性别参与者的底部10%或20%。使用触摸屏型痴呆评估量表评估认知功能，并测量臂踝脉搏波速度作为动脉僵硬度的指标。男性和女性受试者的肌肉减少指数与臂踝脉搏波速度适度但显著相关。WMH的存在与男性大腿肌肉CSA低和女性骨骼肌质量低显着相关。触摸屏型痴呆评估量表评分与男性大腿肌肉CSA和女性骨骼肌质量呈中度但显著正相关。在两个肌肉减少指数的底部10%的参与者中，肌肉质量下降与女性的认知障碍显著且独立相关。较低的肌肉减少指数与较低的认知得分显著相关。动脉僵硬和WMH至少可以部分解释这种关联。
There is a close association between frailty and cognitive impairment. However, the underlying contribution of sarcopenia to the development of cognitive impairment is unclear. We investigated the possible association between muscle mass decline and cognitive impairment in a cross‐sectional study of 1518 subjects aged 55 years or above. We also evaluated arterial stiffness and white matter hyperintensities (WMHs) as possible underlying mechanisms for this association. Two sarcopenic indices were measured: thigh muscle cross‐sectional area (CSA; calculated by computed tomography) and skeletal muscle mass (bioelectric impedance). Muscle mass decline was defined as either the bottom 10% or 20% of participants for each sex. Cognitive function was assessed using the Touch Panel‐type Dementia Assessment Scale, and brachial–ankle pulse wave velocity was measured as an index of arterial stiffness. Both sarcopenic indices were modestly but significantly associated with brachial–ankle pulse wave velocity in male and female subjects. The presence of WMHs was significantly associated with low thigh muscle CSA in men and with low skeletal muscle mass in women. The Touch Panel‐type Dementia Assessment Scale score was modestly but significantly and positively associated with thigh muscle CSA in men and skeletal muscle mass in women. Muscle mass decline in the bottom 10% of participants on both sarcopenic indices was significantly and independently related to cognitive impairment in women. Lower sarcopenic indices are significantly related to lower cognitive scores. Arterial stiffness and WMHs could account, at least in part, for this association.
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DOI：
10.1161/hypertensionaha.115.06610
发表时间：
2016-03
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Pase MP;Himali JJ;Mitchell GF;Beiser A;Maillard P;Tsao C;Larson MG;DeCarli C;Vasan RS;Seshadri S
通讯作者：
Seshadri S
影响因子：
4.4
作者：
Mehrabian, Shima;Duron, Emmanuelle;Hanon, Olivier
通讯作者：
Hanon, Olivier
影响因子：
4.1
作者：
Papachristou, Efstathios;Ramsay, Sheena E.;Wannamethee, S. Goya
通讯作者：
Wannamethee, S. Goya
影响因子：
6.7
作者：
van Kan, Gabor Abellan;Cesari, Matteo;Rolland, Yves
通讯作者：
Rolland, Yves
影响因子：
3.2
作者：
Ries, Julie D.;Echternach, John L.;Blodgett, Michelle Gagnon
通讯作者：
Blodgett, Michelle Gagnon