Dynamics of midgut microflora and dengue virus impact on life history traits in Aedes aegypti.
Dynamics of midgut microflora and dengue virus impact on life history traits in Aedes aegypti.
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DOI：
10.1016/j.actatropica.2014.07.015
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发表时间：
2014-12
期刊：
影响因子：
2.7
通讯作者：
Severson, David W.
中科院分区：
文献类型：
--
作者：
Hill, Casey L.;Sharma, Avinash;Shouche, Yogesh;Severson, David W.
登革热病毒感染后的显着发病率和潜在死亡率是一个重新出现的全球健康问题。由于当前疾病控制方法的有效性有限，蚊子生物学家一直在寻找控制登革热传播的新方法。虽然很多努力都集中在确定载体能力的遗传方面，但副转基因方法也可以揭示新的载体控制策略。蚊子中肠微生物区系和病原体的相互作用可能在媒介生物学中发挥重要作用。然而，很少有人研究微生物组如何影响宿主的适应性和最终的载体能力。在这里，我们研究了中肠微生物环境和登革热感染对登革热病毒初级载体埃及伊蚊的三种品系的一些适应性特征的影响。这包括比较有和没有正常中肠菌群的女性的登革热感染率。根据我们的研究结果，微生物清除或登革热病毒感染后对健康特征的影响几乎不明显。成虫的存活率因菌株的不同而显着不同，其中一种菌株的存活率因抗生素治疗的不同而不同。由于抗生素清除微生物，一种菌株的繁殖力发生变化，但两种处理均未观察到繁殖力发生变化。我们在这里展示 Ae 的健身特征。埃及伊蚊菌株之间差异很大，包括对微生物群存在或不存在的反应不同，但对登革热病毒感染的反应没有变化。
Significant morbidity and potential mortality following dengue virus infection is a re-emerging global health problem. Due to the limited effectiveness of current disease control methods, mosquito biologists have been searching for new methods of controlling dengue transmission. While much effort has concentrated on determining genetic aspects to vector competence, paratransgenetic approaches could also uncover novel vector control strategies. The interactions of mosquito midgut microflora and pathogens may play significant roles in vector biology. However, little work has been done to see how the microbiome influences the host's fitness and ultimately vector competence. Here we investigated the effects of the midgut microbial environment and dengue infection on several fitness characteristics among three strains of the primary dengue virus vector mosquito Aedes aegypti. This included comparisons of dengue infection rates of females with and without their normal midgut flora. According to our findings, few effects on fitness characteristics were evident following microbial clearance or with dengue virus infection. Adult survivorship significantly varied due to strain and in one strain varied due to antibiotic treatment. Fecundity varied in one strain due to microbial clearance by antibiotics but no variation was observed in fertility due to either treatment. We show here that fitness characteristics of Ae. aegypti vary largely between strains, including varying response to microflora presence or absence, but did not vary in response to dengue virus infection.
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影响因子：
3.7
作者：
Apte-Deshpande A;Paingankar M;Gokhale MD;Deobagkar DN
通讯作者：
Deobagkar DN
DOI：
10.4269/ajtmh.1996.54.214
发表时间：
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发表时间：
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作者：
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通讯作者：
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