The rise of the starlet sea anemone Nematostella vectensis as a model system to investigate development and regeneration.
The rise of the starlet sea anemone Nematostella vectensis as a model system to investigate development and regeneration.
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DOI：
10.1002/wdev.222
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发表时间：
2016-07
影响因子：
--
通讯作者：
Rottinger, Eric
中科院分区：
文献类型：
--
作者：
Layden, Michael J.;Rentzsch, Fabian;Rottinger, Eric
反向遗传学和下一代测序开启了生物学的新时代。现在可以识别具有与特定问题最相关的独特生物学的动物，并快速生成从功能上剖析该生物学的工具。这篇综述强调了这样一种新型模型系统的兴起，即小星海葵 Nematostella vectensis。 Nematostella 是一种刺胞动物（珊瑚、水母、水螅、海葵等）动物，最初是 EvoDevo 研究人员的目标，目的是寻找一种刺胞动物，以与两侧对称动物（昆虫、蠕虫、棘皮动物、脊椎动物、软体动物等）的发育进行比较。对线虫的研究已经实现了这一目标，并让我们了解了两侧对称动物关键特征的进化。然而，Nematostella 现在已经超出了其预期用途，有潜力作为模型来更好地了解再生生物学、EcoDevo 或应激反应等其他领域。本综述旨在重点介绍线虫属的 EvoDevo 关键见解，这些见解可指导我们对两侧对称动物的轴向模式机制、中胚层和神经系统的进化的理解，并简要讨论线虫属作为模型的潜力，以更好地理解发育和再生之间的关系。最后，迄今为止对线虫的研究总和已经产生了各种工具，帮助线虫形成一个可行的模型系统。我们提供了当前可用资源和技术的目录，以方便有兴趣将线虫纳入其研究的研究人员。 WIRE 开发生物学 2016 年，5：408–428。 doi: 10.1002/wdev.222 如需与本文相关的更多资源，请访问 WIREs 网站。
Reverse genetics and next‐generation sequencing unlocked a new era in biology. It is now possible to identify an animal(s) with the unique biology most relevant to a particular question and rapidly generate tools to functionally dissect that biology. This review highlights the rise of one such novel model system, the starlet sea anemone Nematostella vectensis. Nematostella is a cnidarian (corals, jellyfish, hydras, sea anemones, etc.) animal that was originally targeted by EvoDevo researchers looking to identify a cnidarian animal to which the development of bilaterians (insects, worms, echinoderms, vertebrates, mollusks, etc.) could be compared. Studies in Nematostella have accomplished this goal and informed our understanding of the evolution of key bilaterian features. However, Nematostella is now going beyond its intended utility with potential as a model to better understand other areas such as regenerative biology, EcoDevo, or stress response. This review intends to highlight key EvoDevo insights from Nematostella that guide our understanding about the evolution of axial patterning mechanisms, mesoderm, and nervous systems in bilaterians, as well as to discuss briefly the potential of Nematostella as a model to better understand the relationship between development and regeneration. Lastly, the sum of research to date in Nematostella has generated a variety of tools that aided the rise of Nematostella to a viable model system. We provide a catalogue of current resources and techniques available to facilitate investigators interested in incorporating Nematostella into their research. WIREs Dev Biol 2016, 5:408–428. doi: 10.1002/wdev.222 For further resources related to this article, please visit the WIREs website.
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