Evidence for opioid involvement in the motivation to sing.
Evidence for opioid involvement in the motivation to sing.
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DOI：
10.1016/j.jchemneu.2009.03.008
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发表时间：
2010-03
影响因子：
2.8
通讯作者：
Riters LV
中科院分区：
文献类型：
--
作者：
Riters LV
鸣禽在多种社会背景下发出高频率的歌曲，这表明它们唱歌的动机很高，而且歌曲制作本身可能是有益的。在理解歌曲学习和感觉运动处理的神经基础方面已经取得了进展，但对调节唱歌动机的神经生物学机制知之甚少。涉及动机和奖励的神经系统在各个物种中都是保守的，鸣禽在神经解剖学上处于有利的位置来影响鸣叫控制系统。这些系统中的阿片类神经肽在享乐奖励中发挥着主要作用，至少在哺乳动物中是这样。在鸣禽中，阿片类神经肽和受体遍布于整个鸣叫控制系统以及与动机和奖励有关的几个大脑区域，包括内侧视前核（POM）和腹侧被盖区（VTA）。越来越多的研究表明，这些区域在鸟鸣中发挥着不同的作用，具体取决于鸣叫是否出于对雌鸟的性动机反应、用于领土防御或作为群体的一部分而歌唱但不针对个体（无定向鸣叫）。阿片类药物的药理学操作和免疫细胞化学数据表明，阿片类药物的活性可能在 VTA 和 POM 中发挥着调节歌曲产生的作用。尽管还需要进一步的研究，但数据表明，阿片类药物可能在强化鸣叫方面发挥着最重要的作用，但不会导致任何明显形式的立即外部介导的强化，例如在大群中或在鸣叫学习过程中产生的无定向鸣叫。数据审查支持这样的观点：多巴胺活动是唱歌动机或驱动力的基础，但阿片类药物的释放才是歌曲制作带来回报的原因。
Songbirds produce high rates of song within multiple social contexts, suggesting that they are highly motivated to sing and that song production itself may be rewarding. Progress has been made in understanding the neural basis of song learning and sensorimotor processing, however little is known about neurobiological mechanisms regulating the motivation to sing. Neural systems involved in motivation and reward have been conserved across species and in songbirds are neuroanatomically well-positioned to influence the song control system. Opioid neuropeptides within these systems play a primary role in hedonic reward, at least in mammals. In songbirds, opioid neuropeptides and receptors are found throughout the song control system and within several brain regions implicated in both motivation and reward, including the medial preoptic nucleus (POM) and ventral tegmental area (VTA). Growing research shows these regions to play a role in birdsong that differs depending upon whether song is sexually-motivated in response to a female, used for territorial defense or sung as part of a flock but not directed towards an individual (undirected song). Opioid pharmacological manipulations and immunocytochemical data demonstrate a role for opioid activity possibly within VTA and POM in the regulation of song production. Although future research is needed, data suggest that opioids may be most critically involved in reinforcing song that does not result in any obvious form of immediate externally-mediated reinforcement, such as undirected song produced in large flocks or during song learning. Data are reviewed supporting the idea that dopamine activity underlies the motivation or drive to sing, but that opioid release is what makes song production rewarding.
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DOI：
10.1016/0278-5846(83)90027-1
发表时间：
1983-01-01
影响因子：
5.6
作者：
BOZARTH, MA;WISE, RA
通讯作者：
WISE, RA
影响因子：
1.9
作者：
AGMO, A;BERENFELD, R
通讯作者：
BERENFELD, R
影响因子：
6.1
作者：
BOZARTH, MA;WISE, RA
通讯作者：
WISE, RA
影响因子：
3.6
作者：
AGMO, A;PAREDES, R
通讯作者：
PAREDES, R
影响因子：
1.7
作者：
Appeltants, D;Ball, GF;Balthazart, J
通讯作者：
Balthazart, J