Physical activity, sedentary behaviours, and the prevention of endometrial cancer.
Physical activity, sedentary behaviours, and the prevention of endometrial cancer.
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DOI：
10.1038/sj.bjc.6605902
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发表时间：
2010-09-28
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
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作者：
人们假设体力活动可以降低子宫内膜癌的风险，但由于前瞻性研究数量有限，这种关系很难得到证实。然而，最近发表的五项队列研究可能有助于解决这个问题，这些研究总共包含已发表文献中 3463 个案例中的 2663 个案例，用于分析休闲体育活动。为了综合这些新数据，我们对截至 2009 年 12 月发表的前瞻性研究进行了荟萃分析。我们发现，体力活动与子宫内膜癌风险降低明显相关，活跃的女性比不活跃的女性患子宫内膜癌的风险大约低 30%。由于最近人们对久坐行为的兴趣，我们利用 NIH-AARP 饮食与健康研究的数据进一步研究了久坐时间与子宫内膜癌风险的关系。我们发现，无论中等强度的体力活动水平如何，久坐时间越长与子宫内膜癌风险增加相关。因此，限制久坐行为的时间可以补充增加中等强度体力活动水平，作为降低子宫内膜癌风险的一种手段。结合已确定的这种关系的生物学合理性，现在的全部证据令人信服地表明体力活动可以预防或降低子宫内膜癌的风险。
Physical activity has been hypothesised to reduce endometrial cancer risk, but this relationship has been difficult to confirm because of a limited number of prospective studies. However, recent publications from five cohort studies, which together comprise 2663 out of 3463 cases in the published literature for analyses of recreational physical activity, may help resolve this question. To synthesise these new data, we conducted a meta-analysis of prospective studies published through to December 2009. We found that physical activity was clearly associated with reduced risk of endometrial cancer, with active women having an approximately 30% lower risk than inactive women. Owing to recent interest in sedentary behaviour, we further investigated sitting time in relation to endometrial cancer risk using data from the NIH-AARP Diet and Health Study. We found that, independent of the level of moderate–vigorous physical activity, greater sitting time was associated with increased endometrial cancer risk. Thus, limiting time in sedentary behaviours may complement increasing level of moderate–vigorous physical activity as a means of reducing endometrial cancer risk. Taken together with the established biological plausibility of this relation, the totality of evidence now convincingly indicates that physical activity prevents or reduces risk of endometrial cancer.
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影响因子：
2.3
作者：
Conroy, Molly B.;Sattelmair, Jacob R.;Cook, Nancy R.;Manson, JoAnn E.;Buring, Julie E.;Lee, I-Min
通讯作者：
Lee, I-Min
影响因子：
5.7
作者：
Owen N;Healy GN;Matthews CE;Dunstan DW
通讯作者：
Dunstan DW
影响因子：
3.8
作者：
Gunter, Marc J.;Hoover, Donald R.;Strickler, Howard D.
通讯作者：
Strickler, Howard D.
影响因子：
6.4
作者：
Patel, Alpa V.;Feigelson, Heather Spencer;Calle, Eugenia E.
通讯作者：
Calle, Eugenia E.
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N