Estimating health of the implanted cochlea using psychophysical strength-duration functions and electrode configuration.
Estimating health of the implanted cochlea using psychophysical strength-duration functions and electrode configuration.
复制标题
使用心理物理强度 - 持续功能和电极构型估算植入的耳蜗的健康。
DOI：
10.1016/j.heares.2021.108404
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发表时间：
2022-03
期刊：
影响因子：
2.8
通讯作者：
Pfingst BE
中科院分区：
文献类型：
--
作者：
Garadat SN;Colesa DJ;Swiderski DL;Raphael Y;Pfingst BE
一般认为，人工耳蜗植入的疗效部分取决于受刺激神经群的状况。耳蜗病理学可能影响神经元对电刺激的反应方式，可能导致耳蜗植入体接受者和单个耳蜗植入体用户的电极阵列之间的电刺激感知差异。几种心理物理和电生理测量已被证明可以预测动物的耳蜗健康状况，并用于评估人类个体刺激部位附近的状况。在这项研究中，我们研究了心理物理强度-持续时间功能和螺旋神经节神经元密度之间的关系，在两组豚鼠人工耳蜗植入谁有最小的重叠耳蜗健康档案。一组植入听力正常的耳中（N = 10），另一组通过耳蜗灌注新霉素，接种具有Ntf 3基因插入物的腺相关病毒载体（AAV.Ntf3）并植入（N = 14）。然后比较两个治疗组的单极和三极电极配置的精神病学测量强度-持续时间函数。还将结果与其组织学结局进行了比较。总体而言，两个治疗组在心理物理表现以及功能表现与组织学数据之间的关系方面存在显著差异。新霉素处理、神经营养素处理和植入组（NNI）的动物表现出更陡的强度-持续时间功能斜率;斜率与SGN密度呈正相关（SGN密度较高的动物斜率更陡）。相比之下，植入听力（IH）组的斜率较浅，斜率和螺旋神经节密度之间没有关系。在所有动物中，斜率与整体自发活动水平呈负相关（斜率越浅，整体自发活动水平越高）。我们假设，两个治疗组之间的强度-持续时间函数斜率的差异与内毛细胞的状况有关，内毛细胞产生自发活动，可能影响跨纤维同步性和/或响应电刺激的神经元群体的大小。此外，在IH组中可能存在螺旋神经节神经元外周突起，其可能影响受刺激神经元的膜性质。结果表明，两个治疗组表现出不同的模式变化的刺激电极附近的条件，改变检测阈值。总的来说，这项研究的结果表明，人工耳蜗刺激的心理物理检测阈值与植入耳蜗中的神经存活之间存在复杂的关系。这种关系似乎取决于电刺激的特性、电极配置以及植入耳蜗的其他生物学特征，例如内毛细胞和外周突起的状况。
It is generally believed that the efficacy of cochlear implants is partly dependent on the condition of the stimulated neural population. Cochlear pathology is likely to affect the manner in which neurons respond to electrical stimulation, potentially resulting in differences in perception of electrical stimuli across cochlear implant recipients and across the electrode array in individual cochlear implant users. Several psychophysical and electrophysiological measures have been shown to predict cochlear health in animals and were used to assess conditions near individual stimulation sites in humans. In this study we examined the relationship between psychophysical strength-duration functions and spiral ganglion neuron density in two groups of guinea pigs with cochlear implants who had minimally-overlapping cochlear health profiles. One group was implanted in a hearing ear (N = 10) and the other group was deafened by cochlear perfusion of neomycin, inoculated with an adeno-associated viral vector with an Ntf3-gene insert (AAV.Ntf3) and implanted (N = 14). Psychophysically measured strength-duration functions for both monopolar and tripolar electrode configurations were then compared for the two treatment groups. Results were also compared to their histological outcomes. Overall, there were considerable differences between the two treatment groups in terms of their psychophysical performance as well as the relation between their functional performance and histological data. Animals in the neomycin-deafened, neurotrophin-treated, and implanted group (NNI) exhibited steeper strength-duration function slopes; slopes were positively correlated with SGN density (steeper slopes in animals that had higher SGN densities). In comparison, the implanted hearing (IH) group had shallower slopes and there was no relation between slopes and spiral ganglion density. Across all animals, slopes were negatively correlated with ensemble spontaneous activity levels (shallower slopes with higher ensemble spontaneous activity levels). We hypothesize that differences in strength-duration function slopes between the two treatment groups were related to the condition of the inner hair cells, which generate spontaneous activity that could affect the across-fiber synchrony and/or the size of the population of neural elements responding to electrical stimulation. In addition, it is likely that spiral ganglion neuron peripheral processes were present in the IH group, which could affect membrane properties of the stimulated neurons. Results suggest that the two treatment groups exhibited distinct patterns of variation in conditions near the stimulating electrodes that altered detection thresholds. Overall, the results of this study suggest a complex relationship between psychophysical detection thresholds for cochlear implant stimulation and nerve survival in the implanted cochlea. This relationship seems to depend on the characteristics of the electrical stimulus, the electrode configuration, and other biological features of the implanted cochlea such as the condition of the inner hair cells and the peripheral processes.
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影响因子：
4.2
作者：
Fransson, Anette;Ulfendahl, Mats
通讯作者：
Ulfendahl, Mats
DOI：
10.1002/ar.22586
发表时间：
2012-11
影响因子：
2
作者：
Budenz, Cameron L.;Pfingst, Bryan E.;Raphael, Yehoash
通讯作者：
Raphael, Yehoash
影响因子：
2.8
作者：
COLOMBO, J;PARKINS, CW
通讯作者：
PARKINS, CW
影响因子：
2.4
作者：
Chatterjee, Monita;Kulkarni, Aditya M.
通讯作者：
Kulkarni, Aditya M.
影响因子：
2.8
作者：
Javel, E;Shepherd, RK
通讯作者：
Shepherd, RK