Surface-engineered nanomaterials as X-ray absorbing adjuvant agents for Auger-mediated chemo-radiation.
Surface-engineered nanomaterials as X-ray absorbing adjuvant agents for Auger-mediated chemo-radiation.
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DOI:
10.1039/c3nr00333g
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发表时间:
2013-06-21
期刊:
影响因子:
6.7
通讯作者:
Cook RF
中科院分区:
文献类型:
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作者:
Lee SM;Tsai DH;Hackley VA;Brechbiel MW;Cook RF
We report a prototype approach to formulate gold nanoparticle-based X-ray absorbing agents through surface-engineering of a cisplatin pharmacophore with modified polyacrylate. The resulting agents exhibit both chemo-therapeutic potency to cancer cells and Auger-mediated secondary electron emission, showing great potential to improve the therapeutic efficacy of chemo-radiation.
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影响因子:
15
作者:
Brown, Sarah D.;Nativo, Paola;Smith, Jo-Ann;Stirling, David;Edwards, Paul R.;Venugopal, Balaji;Flint, David J.;Plumb, Jane A.;Graham, Duncan;Wheate, Nial J.
通讯作者:
Wheate, Nial J.
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Burda, Clemens
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Xing, James Z.
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通讯作者:
Pitzer, Russell M.
影响因子:
38.3
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