Hippocampal viscoelasticity and episodic memory performance in healthy older adults examined with magnetic resonance elastography.
Hippocampal viscoelasticity and episodic memory performance in healthy older adults examined with magnetic resonance elastography.
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DOI：
10.1007/s11682-018-9988-8
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发表时间：
2020-02
影响因子：
3.2
通讯作者：
Starr JM
中科院分区：
文献类型：
--
作者：
Hiscox LV;Johnson CL;McGarry MDJ;Schwarb H;van Beek EJR;Roberts N;Starr JM
情景记忆对正常老化特别敏感;然而，研究支持情景记忆的结构-功能关系的研究主要限于脑组织健康的总体积测量。磁共振弹性成像（MRE）是一种新兴的非侵入性，高分辨率的成像技术，独特的量化大脑粘弹性，并因此，提供了一个更具体的衡量神经微结构的完整性。最近，在年轻人中观察到眶额皮质-流体智力和大脑-关系记忆结构-功能关系之间的显著双重分离，突出了敏感的MRE措施用于研究大脑健康及其与认知功能的关系的潜力。然而，MRE观察到的结构-功能关系尚未在健康老年人中进行探索。在这项研究中，我们研究了海马（HC）粘弹性和情景记忆之间的关系，在认知健康的成年人，年龄在66-73岁（N = 11），测量与言语配对联想（VPA）子测试韦氏记忆量表（WMS-R）。鉴于语言记忆任务对左侧HC的特殊依赖性，首次考虑了单侧HC MRE测量。左侧HC阻尼比、VPA和VPA回忆评分之间存在显著负相关（rs =-0.77，p = 0.009），这与之前关于年轻人HC阻尼比和记忆表现之间关系的研究结果一致。相反，右侧HC与VPA回忆评分之间的相关性不显著。这些结果突出了MRE在研究认知能力下降和大脑衰老方面的效用，并表明其可能用作记忆相关障碍的敏感成像生物标志物。
Episodic memory is particularly sensitive to normative aging; however, studies investigating the structure-function relationships that support episodic memory have primarily been limited to gross volumetric measures of brain tissue health. Magnetic resonance elastography (MRE) is an emerging non-invasive, high-resolution imaging technique that uniquely quantifies brain viscoelasticity, and as such, provides a more specific measure of neural microstructural integrity. Recently, a significant double dissociation between orbitofrontal cortex-fluid intelligence and hippocampal-relational memory structure-function relationships was observed in young adults, highlighting the potential of sensitive MRE measures for studying brain health and its relation to cognitive function. However, the structure-function relationship observed by MRE has not yet been explored in healthy older adults. In this study, we examined the relationship between hippocampal (HC) viscoelasticity and episodic memory in cognitively healthy adults aged 66–73 years (N = 11), as measured with the verbal-paired associates (VPA) subtest from the Wechsler Memory Scale (WMS-R). Given the particular dependence of verbal memory tasks on the left HC, unilateral HC MRE measurements were considered for the first time. A significant negative correlation was found between left HC damping ratio, ξ and VPA recall score (rs = −0.77, p = 0.009), which is consistent with previous findings of a relationship between HC ξ and memory performance in young adults. Conversely, correlations between right HC ξ with VPA recall score were not significant. These results highlight the utility of MRE to study cognitive decline and brain aging and suggest its possible use as a sensitive imaging biomarker for memory-related impairments.
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影响因子：
3.5
作者：
Erickson, Kirk I.;Prakash, Ruchika S.;Voss, Michelle W.;Chaddock, Laura;Hu, Liang;Morris, Katherine S.;White, Siobhan M.;Wojcicki, Thomas R.;McAuley, Edward;Kramer, Arthur F.
通讯作者：
Kramer, Arthur F.
影响因子：
4.2
作者：
Hiscox LV;Johnson CL;McGarry MDJ;Perrins M;Littlejohn A;van Beek EJR;Roberts N;Starr JM
通讯作者：
Starr JM
影响因子：
3.7
作者：
HAMPEL, FR
通讯作者：
HAMPEL, FR
影响因子：
3.7
作者：
Bondi, MW;Salmon, DP;Thal, LJ
通讯作者：
Thal, LJ
影响因子：
--
作者：
Fama, Rosemary;Sullivan, Edith V
通讯作者：
Sullivan, Edith V