Neural responses to incongruency in a blocked-trial Stroop fMRI task in major depressive disorder.
Neural responses to incongruency in a blocked-trial Stroop fMRI task in major depressive disorder.
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DOI：
10.1016/j.jad.2012.05.016
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发表时间：
2012-12-20
影响因子：
6.6
通讯作者：
Keilp, John G.
中科院分区：
文献类型：
--
作者：
Kikuchi, Toshiaki;Miller, Jeffrey M.;Schneck, Noam;Oquendo, Maria A.;Mann, J. John;Parsey, Ramin V.;Keilp, John G.
关键词：
重度抑郁症（MDD）患者在Stroop任务中表现不佳，Stroop任务是一种测量注意力执行控制的方法，干扰分辨率受损。这种缺陷的神经相关性没有得到很好的描述。为了研究这种缺陷如何与MDD的病理生理异常相关，我们进行了一项功能磁共振成像Stroop研究，将MDD受试者与对照组进行比较。42名未用药的MDD患者和17名对照受试者接受了色词Stroop任务的fMRI扫描。受试者在交替颜色识别过程中评估字体颜色（例如，蓝色的“”）和不一致的颜色/单词块（例如，“红色”是蓝色的。我们检查了神经激活，其在不一致块中大于颜色识别块（Z>2.3，校正p<0.05），控制了逐个试验的反应时间。与对照组相比，MDD受试者在多个脑区（包括额中回、扣带回旁和后扣带回、楔前叶、枕区和脑干）的不一致阻滞期间表现出较低的激活。没有发现MDD受试者在不一致块中比对照组更活跃的大脑区域。并非所有MDD受试者均未接受过抗抑郁药治疗。与对照组相比，MDD受试者在处理不一致刺激时，与执行功能、视觉处理和语义处理相关的脑区不太活跃。MDD中的注意力缺陷可能是未能以持续的方式在分布式网络中保持活动的产物，正如在该块设计中的顺序试验中所要求的那样。进一步的研究可能会澄清这些异常是否代表一种特质或状态缺陷。
Patients with major depressive disorder (MDD) perform poorly on the Stroop task, which is a measure of the executive control of attention, with impaired interference resolution. The neural correlates of this deficit are not well described. To examine how this deficit relates to pathophysiological abnormalities in MDD, we conducted an fMRI Stroop study comparing MDD subjects to controls. Forty-two unmedicated patients with current MDD and 17 control subjects underwent fMRI scanning with a color-word Stroop task. Subjects assessed font color during alternating color identification (ex. ‘XXXX’ in blue) and incongruent color/word blocks (ex. the word ‘red’ in blue). We examined neural activation that was greater in incongruent than color identification blocks (Z>2.3 and corrected p<0.05), controlling for trial-by-trial reaction time. Compared to controls, MDD subjects exhibited lower activation during incongruent blocks across multiple brain regions, including middle frontal gyrus, paracingulate and posterior cingulate, precuneus, occipital regions, and brain stem. No brain regions were identified in which MDD subjects were more active than controls during incongruent blocks. Not all MDD subjects were antidepressant-naïve. Brain regions related to executive function, visual processing, and semantic processing are less active during processing of incongruent stimuli in MDD subjects as compared to controls. Deficits of attention in MDD may be the product of a failure to maintain activity across a distributed network in a sustained manner, as is required over the sequential trials in this block design. Further studies may clarify whether the abnormalities represent a trait or state deficit.
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影响因子：
11.3
作者：
Keilp, John G.;Gorlyn, Marianne;Mann, J. John
通讯作者：
Mann, J. John
影响因子：
11.3
作者：
LeGris, Jeannette;Links, Paul S.;Toplak, Maggie
通讯作者：
Toplak, Maggie
影响因子：
2.9
作者：
Nee, Derek Evan;Wager, Tor D.;Jonides, John
通讯作者：
Jonides, John
影响因子：
3.7
作者：
Leung, HC;Skudlarski, P;Gore, JC
通讯作者：
Gore, JC
DOI：
10.1016/s0926-6410(02)00218-5
发表时间：
2002-12-01
期刊：
COGNITIVE BRAIN RESEARCH
影响因子：
--
作者：
Roelofs, A;Hagoort, P
通讯作者：
Hagoort, P