Differential neural activity during search of specific and general autobiographical memories elicited by musical cues.
Differential neural activity during search of specific and general autobiographical memories elicited by musical cues.
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DOI：
10.1016/j.neuropsychologia.2011.04.032
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发表时间：
2011-07
期刊：
影响因子：
2.6
通讯作者：
Giovanello KS
中科院分区：
文献类型：
--
作者：
Ford JH;Addis DR;Giovanello KS
先前检测自传体记忆特异性的神经成像研究利用了与先前对事件的搜索相关的提取线索，潜在地改变了正在研究的提取过程。在目前的研究中，音乐线索被用来自然地从多个特定水平(即，一生时期、一般事件和特定事件)引发记忆。16名年轻人参与了一项神经成像研究，在这项研究中，他们找回了与音乐线索相关的自传性记忆。这些音乐线索导致了对先前检索水平较低的高度情绪化记忆的检索。所有自传体记忆水平的恢复与自传体记忆网络区域的活动有关，特别是腹内侧前额叶皮质、后扣带回和右内侧颞叶。由于音乐的使用，提取了不同程度的特定记忆，允许比较事件记忆和抽象的个人知识，以及比较具体和一般的事件记忆。与个人知识提取相比，事件提取过程中涉及背外侧和背内侧前额叶区域，与一般事件记忆提取相比，特定事件记忆的提取与双侧内侧颞叶和背内侧前额叶皮质的活动增加相关。这些结果表明，对不同专一性水平的记忆的初始搜索过程优先涉及自传体记忆网络的不同组成部分。讨论了这些神经差异的潜在潜在原因。
Previous neuroimaging studies that have examined autobiographical memory specificity have utilized retrieval cues associated with prior searches of the event, potentially changing the retrieval processes being investigated. In the current study, musical cues were used to naturally elicit memories from multiple levels of specificity (i.e., lifetime period, general event, and event-specific). Sixteen young adults participated in a neuroimaging study in which they retrieved autobiographical memories associated with musical cues. These musical cues led to the retrieval of highly emotional memories that had low levels of prior retrieval. Retrieval of all autobiographical memory levels was associated with activity in regions in the autobiographical memory network, specifically the ventromedial prefrontal cortex, posterior cingulate, and right medial temporal lobe. Owing to the use of music, memories from varying levels of specificity were retrieved, allowing for comparison of event memory and abstract personal knowledge, as well as comparison of specific and general event memory. Dorsolateral and dorsomedial prefrontal regions were engaged during event retrieval relative to personal knowledge retrieval, and retrieval of specific event memories was associated with increased activity in the bilateral medial temporal lobe and dorsomedial prefrontal cortex relative to retrieval of general event memories. These results suggest that the initial search processes for memories of different specificity levels preferentially engage different components of the autobiographical memory network. The potential underlying causes of these neural differences are discussed.
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