Quantitative susceptibility mapping in the human fetus to measure blood oxygenation in the superior sagittal sinus.
Quantitative susceptibility mapping in the human fetus to measure blood oxygenation in the superior sagittal sinus.
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DOI：
10.1007/s00330-018-5735-1
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发表时间：
2019-04
影响因子：
5.9
通讯作者：
Neelavalli J
中科院分区：
文献类型：
--
作者：
Yadav BK;Buch S;Krishnamurthy U;Jella P;Hernandez-Andrade E;Trifan A;Yeo L;Hassan SS;Mark Haacke E;Romero R;Neelavalli J
提出对人类胎儿进行定量磁敏图（QSM）以评估体内脑静脉血氧合（SvO2）的可行性。磁敏感加权成像 (SWI) 数据来自健康怀孕受试者（n = 21，中位数 = 31.3 周，IQR = 8.8 周）。磁敏图是使用经过修改的 QSM 处理流程从 SWI 相图像生成的，并针对胎儿应用进行了优化。处理流程如下：（1）轻度高通滤波，然后对相位图像进行二次拟合以消除背景相位变化； (2) 手动制作包含上矢状窦（SSS）的胎儿脑罩； (3)使用具有几何约束的截断k空间方法对所得掩模相位图像进行逆滤波。此外，根据生成的磁化率图对 SSS 的磁化率 Δχv 和相应的推定 SvO2 进行了量化。还通过模拟研究了因改进管道而导致的测量 SvO2 的系统误差。模拟表明，当使用包含 SSS 周围至少 5 个体素和 5 个切片的掩模时，对于血管相对于主磁场的不同方向，SvO2 的系统误差仍然小于 3%。所有妊娠期 SSS 的平均 Δχv 为 0.42±0.03 ppm。根据 Δχv，所有胎儿 SSS 中的平均推定 SvO2 为 67%±7%，这与已发表的研究非常一致。这项体内研究证明了在人类胎儿大脑中使用 QSM 来估计 Δχv 和 SvO2 的可行性。
To present the feasibility of performing quantitative susceptibility mapping (QSM) in the human fetus to evaluate the oxygenation (SvO2) of cerebral venous blood in-vivo. Susceptibility weighted imaging (SWI) data was acquired from healthy pregnant subjects (n=21, median=31.3weeks, IQR=8.8weeks). The susceptibility maps were generated from the SWI-phase images using a modified QSM processing pipeline, optimized for fetal applications. The processing pipeline is as follows: (1) mild high-pass filtering followed by quadratic fitting of the phase images to eliminate background phase variations; (2) manual creation of a fetal brain mask that includes the superior sagittal sinus (SSS); and (3) inverse filtering of the resultant masked phase images using a truncated k-space approach with geometric constraint. Further, the magnetic susceptibility, Δχv and corresponding putative SvO2 of the SSS were quantified from the generated susceptibility maps. Systematic error in the measured SvO2 due to the modified pipeline was also studied through simulations. Simulations showed that the systematic error in SvO2 when using a mask that includes a minimum of 5 voxels around the SSS and 5 slices remains <3% for different orientations of the vessel relative to the main magnetic field. The average Δχv in the SSS quantified across all gestations was 0.42±0.03 ppm. Based on Δχv, the average putative SvO2 in the SSS across all fetuses was 67%±7%, which is in good agreement with published studies. This in-vivo study demonstrates the feasibility of using QSM in the human fetal brain to estimate Δχv and SvO2.
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影响因子：
2.1
作者：
Gunn AJ;Bennet L
通讯作者：
Bennet L
影响因子：
4.4
作者：
Haacke, E. M.;Tang, J.;Neelavalli, J.;Cheng, Y. C. N.
通讯作者：
Cheng, Y. C. N.
DOI：
10.1016/s0002-9378(85)80205-2
发表时间：
1985-01-01
影响因子：
9.8
作者：
LOW, JA;GALBRAITH, RS;KARCHMAR, EJ
通讯作者：
KARCHMAR, EJ
影响因子：
2.2
作者：
BOULOT, P;CATTANEO, A;VIALA, JL
通讯作者：
VIALA, JL
影响因子：
2.9
作者：
Deistung, Andreas;Schweser, Ferdinand;Reichenbach, Juergen R.
通讯作者：
Reichenbach, Juergen R.