Overlapping neurobiology of learned helplessness and conditioned defeat: implications for PTSD and mood disorders.
Overlapping neurobiology of learned helplessness and conditioned defeat: implications for PTSD and mood disorders.
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DOI：
10.1016/j.neuropharm.2011.02.024
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发表时间：
2012-02
影响因子：
4.7
通讯作者：
Lezak, Kimberly R.
中科院分区：
文献类型：
--
作者：
Hammack, Sayamwong E.;Cooper, Matthew A.;Lezak, Kimberly R.
关键词：
暴露在创伤事件中会增加患严重抑郁障碍(MDD)和创伤后应激障碍(PTSD)的风险，这些疾病的药物治疗通常涉及到5-羟色胺(5-HT)系统的调节。在啮齿动物中，有几种行为模式会产生类似MDD症状的行为变化，这些行为变化对抗抑郁药物治疗很敏感。在这里，我们回顾了两个动物模型，在这些动物模型中，成年期间暴露于急性创伤事件、习得性无助和条件性失败会引发类似MDD的行为变化。在LH期，大鼠暴露在不可避免但不是不可避免的尾部休克中，会产生一系列行为变化，包括战斗/逃跑反应的缺陷和焦虑样行为的增强。在条件性失败中，叙利亚仓鼠遭受更具攻击性的动物的社会失败会导致领土攻击性的丧失，并在随后遇到非攻击性同种动物时增加顺从和防御行为。对控制黄体生成素和条件性失败的神经底物的研究表明，中缝背核(DRN)中5-羟色胺活性的增加对这两种模型都是至关重要的。在这两种范式中，调节行为习得和/或行为表达的其他关键脑区包括杏仁基底外侧核(BLA)、杏仁中央核(CEA)和终纹床核(BNST)。在这篇综述中，我们比较和对比了这些神经结构中的每一个在调节黄体生成素和条件性失败中的作用，并讨论了这些数据在更好地理解创伤相关抑郁的潜在机制方面的相关性。
Exposure to traumatic events can increase the risk for major depressive disorder (MDD) as well as posttraumatic stress disorder (PTSD), and pharmacological treatments for these disorders often involve the modulation of serotonergic (5-HT) systems. Several behavioral paradigms in rodents produce changes in behavior that resemble symptoms of MDD and these behavioral changes are sensitive to antidepressant treatments. Here we review two animal models in which MDD-like behavioral changes are elicited by exposure to an acute traumatic event during adulthood, learned helplessness (LH) and conditioned defeat. In LH, exposure of rats to inescapable, but not escapable, tailshock produces a constellation of behavioral changes that include deficits in fight/flight responding and enhanced anxiety-like behavior. In conditioned defeat, exposure of Syrian hamsters to a social defeat by a more aggressive animal leads to a loss of territorial aggression and an increase in submissive and defensive behaviors in subsequent encounters with non-aggressive conspecifics. Investigations into the neural substrates that control LH and conditioned defeat revealed that increased 5-HT activity in the dorsal raphe nucleus (DRN) is critical for both models. Other key brain regions that regulate the acquisition and/or expression of behavior in these two paradigms include the basolateral amygdala (BLA), central nucleus of the amygdala (CeA) and bed nucleus of the stria terminalis (BNST). In this review, we compare and contrast the role of each of these neural structures in mediating LH and conditioned defeat, and discuss the relevance of these data in developing a better understanding of the mechanisms underlying trauma-related depression.
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影响因子：
10.6
作者：
Christianson, John P.;Ragole, Thomas;Amat, Jose;Greenwood, Benjamin N.;Strong, Paul V.;Paul, Evan D.;Fleshner, Monika;Watkins, Linda R.;Maier, Steven F.
通讯作者：
Maier, Steven F.
DOI：
10.1017/s1461145701002632
发表时间：
2001-12-01
影响因子：
4.8
作者：
Bagdy, G;Graf, M;Kantor, S
通讯作者：
Kantor, S
影响因子：
10.6
作者：
Burghardt, NS;Sullivan, GM;LeDoux, JE
通讯作者：
LeDoux, JE
影响因子：
2.9
作者：
Amat, J;Matus-Amat, P;Maier, SF
通讯作者：
Maier, SF
影响因子：
10.5
作者：
Bleich, A;Koslowsky, M;Lerer, B
通讯作者：
Lerer, B