Inverse J-Shaped Relationship of Dietary Carbohydrate Intake with Serum Klotho in NHANES 2007-2016.
Inverse J-Shaped Relationship of Dietary Carbohydrate Intake with Serum Klotho in NHANES 2007-2016.
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DOI：
10.3390/nu15183956
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发表时间：
2023-09-13
期刊：
影响因子：
5.9
通讯作者：
Xiao L
中科院分区：
文献类型：
--
作者：
Xiang L;Wu M;Wang Y;Liu S;Lin Q;Luo G;Xiao L
背景：膳食碳水化合物摄入量与血清 Klotho 水平（一种衰老生物标志物）之间的关系仍不确定。目的：本研究旨在调查 40-79 岁美国成年人膳食碳水化合物摄入量与血清 Klotho 水平之间的关系。方法：我们分析了 2007 年至 2016 年参加国家健康和营养检查调查 (NHANES) 的 10,669 名 40-79 岁成年人的数据。训练有素的访谈者使用 24 小时饮食回忆评估膳食碳水化合物摄入量。使用日本 IBL International 提供的市售 ELISA 试剂盒测量血清 Klotho 浓度，作为研究结果。使用广义线性模型来评估碳水化合物能量百分比和血清 Klotho 浓度之间的关系，并使用限制三次样条 (RCS) 分析来探索任何非线性关联。结果：调整多个变量后，我们观察到碳水化合物能量百分比与血清 Klotho 水平之间存在非线性逆 J 形关系（非线性 p < 0.001）。具体来说，最高的血清 Klotho 水平与总碳水化合物能量百分比范围从 48.92% 到 56.20%（第三个四分位数）相关。当以四分位数评估碳水化合物能量百分比时，第一个四分位数（<41.46%）中血清Klotho水平下降了5.37%（95% CI：-7.43%，-3.26%）、2.70%（95% CI：-4.51%，-0.86%）和2.76%（95% CI：-4.86%，-0.62%），与第三个四分位数相比，分别为第二个四分位数（41.46％至48.92％）和第四个四分位数（≥56.20％）。这种关系在 60 岁以下的男性、非肥胖和非糖尿病参与者中更为明显。结论：美国中老年人群碳水化合物能量百分比与血清 Klotho 水平之间存在非线性逆 J 形关系，在碳水化合物摄入量为 48.92% 至 56.20% 时观察到最高水平。
Background: The relationship between dietary carbohydrate intake and serum Klotho levels, an aging biomarker, remains uncertain. Objective: This study aimed to investigate the association between dietary carbohydrate intake and serum Klotho levels among American adults aged 40–79. Methods: We analyzed data from 10,669 adults aged 40–79 years who participated in the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2016. Trained interviewers assessed dietary carbohydrate intake using a 24 h dietary recall. Serum Klotho concentrations were measured using commercially available ELISA kits provided by IBL International, Japan, which served as the study outcome. Generalized linear models were used to assess the relationship between the carbohydrate energy percentage and serum Klotho concentration, and restricted cubic spline (RCS) analysis was employed to explore any nonlinear associations. Results: After adjusting for multiple variables, we observed a nonlinear inverse J-shaped relationship (p for non-linearity < 0.001) between the carbohydrate energy percentage and serum Klotho levels. Specifically, the highest serum Klotho levels were associated with a total carbohydrate energy percentage ranging from 48.92% to 56.20% (third quartile). When the carbohydrate energy percentage was evaluated in quartiles, serum Klotho levels decreased by 5.37% (95% CI: −7.43%, −3.26%), 2.70% (95% CI: −4.51%, −0.86%), and 2.76% (95% CI: −4.86%, −0.62%) in the first quartile (<41.46%), second quartile (41.46% to 48.92%), and fourth quartile (≥56.20%), respectively, compared to the third quartile. This relationship was more pronounced in male, non-obese and non-diabetic participants under 60 years of age. Conclusion: A non-linear inverse J-shaped relationship exists among the general U.S. middle-aged and older population between the carbohydrate energy percentage and serum Klotho levels, with the highest levels observed at 48.92% to 56.20% carbohydrate intake.
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