Neural FoxP2 and FoxP1 expression in the budgerigar, an avian species with adult vocal learning.
Neural FoxP2 and FoxP1 expression in the budgerigar, an avian species with adult vocal learning.
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DOI：
10.1016/j.bbr.2015.01.017
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发表时间：
2015-04-15
影响因子：
2.7
通讯作者：
Wright, Timothy F.
中科院分区：
文献类型：
--
作者：
Hara, Erina;Perez, Jemima M.;Whitney, Osceola;Chen, Qianqian;White, Stephanie A.;Wright, Timothy F.
声音学习是人类获得语言和某些鸟类获得声音信号的基础。这些鸟类群体和人类表现出趋同的发展阶段和相关的大脑通路的声音沟通。转录因子FoxP2在人类和鸣禽的发声学习中起着关键作用。叉头盒基因家族的另一个成员FoxP1也在参与声音学习和产生的大脑区域中表现出高表达。在这里，我们调查FoxP2和FoxP1的mRNA和蛋白质在成年雄性虎皮鹦鹉（Melopsittacus undulatus），鹦鹉物种，表现出声乐学习作为青少年和成年人。为了研究这些分子在成年声乐学习者，我们比较了它们的表达模式在虎皮鹦鹉纹状体核参与声乐学习，内侧纹状体（MMSt）的大细胞核，在鸟类与不同的声乐状态，如发声的女性（定向），单独发声（无定向），和非发声。我们发现，FoxP2 mRNA和蛋白质的表达始终低于在MMSt比在相邻的纹状体，无论声乐状态，而以前的工作表明，鸣禽表现出下调的同源区域，区域X，只有单独唱歌后。相比之下，FoxP1水平在MMSt中高于所有组中的相邻纹状体。综上所述，这些结果加强了一般的假设，FoxP2和FoxP1有专门的表达在发声核群的范围内，并表明，成年人的声音可塑性在虎皮鹦鹉可能是一个产品的持续下调FoxP2在MMSt。
Vocal learning underlies acquisition of both language in humans and vocal signals in some avian taxa. These bird groups and humans exhibit convergent developmental phases and associated brain pathways for vocal communication. The transcription factor FoxP2 plays critical roles in vocal learning in humans and songbirds. Another member of the forkhead box gene family, FoxP1 also shows high expression in brain areas involved in vocal learning and production. Here, we investigate FoxP2 and FoxP1 mRNA and protein in adult male budgerigars (Melopsittacus undulatus), a parrot species that exhibits vocal learning as both juveniles and adults. To examine these molecules in adult vocal learners, we compared their expression patterns in the budgerigar striatal nucleus involved in vocal learning, magnocellular nucleus of the medial striatum (MMSt), across birds with different vocal states, such as vocalizing to a female (directed), vocalizing alone (undirected), and non-vocalizing. We found that both FoxP2 mRNA and protein expressions were consistently lower in MMSt than in the adjacent striatum regardless of the vocal states, whereas previous work has shown that songbirds exhibit downregulation in the homologous region, Area X, only after singing alone. In contrast, FoxP1 levels were high in MMSt compared to the adjacent striatum in all groups. Taken together these results strengthen the general hypothesis that FoxP2 and FoxP1 have specialized expression in vocal nuclei across a range of taxa, and suggest that the adult vocal plasticity seen in budgerigars may be a product of persistent down-regulation of FoxP2 in MMSt.
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影响因子：
2.5
作者：
Jarvis, Erich D.;Yu, Jing;Rivas, Miriam V.;Horita, Haruhito;Feenders, Gesa;Whitney, Osceola;Jarvis, Syrus C.;Jarvis, Electra R.;Kubikova, Lubica;Puck, Ana E. P.;Siang-Bakshi, Connie;Martin, Suzanne;McElroy, Michael;Hara, Erina;Howard, Jason;Pfenning, Andreas;Mouritsen, Henrik;Chen, Chun-Chun;Wada, Kazuhiro
通讯作者：
Wada, Kazuhiro
影响因子：
3.7
作者：
Feenders, Gesa;Liedvogel, Miriam;Rivas, Miriam;Zapka, Manuela;Horita, Haruhito;Hara, Erina;Wada, Kazuhiro;Mouritsen, Henrik;Jarvis, Erich D.
通讯作者：
Jarvis, Erich D.
影响因子：
16.2
作者：
Murugan M;Harward S;Scharff C;Mooney R
通讯作者：
Mooney R
影响因子：
2.9
作者：
Garcia-Calero E;Bahamonde O;Martinez S
通讯作者：
Martinez S
影响因子：
3.9
作者：
Horn, Denise;Kapeller, Johannes;Rivera-Brugues, Nria;Moog, Ute;Lorenz-Depiereux, Bettina;Eck, Sebastian;Hempel, Maja;Wagenstaller, Janine;Gawthrope, Alex;Monaco, Anthony P.;Bonin, Michael;Riess, Olaf;Wohlleber, Eva;Illig, Thomas;Bezzina, Connie R.;Franke, Andre;Spranger, Stephanie;Villavicencio-Lorini, Pablo;Seifert, Wenke;Rosenfeld, Jochen;Klopocki, Eva;Rappold, Gudrun A.;Strom, Tim M.
通讯作者：
Strom, Tim M.