Brief constant light accelerates serotonergic re-entrainment to large shifts of the daily light/dark cycle.
Brief constant light accelerates serotonergic re-entrainment to large shifts of the daily light/dark cycle.
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DOI：
10.1016/j.neuroscience.2009.02.016
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发表时间：
2009-04-10
期刊：
影响因子：
3.3
通讯作者：
Glass, J. D.
中科院分区：
文献类型：
--
作者：
Kaur, G.;Thind, R.;Glass, J. D.
短暂（~2天）持续光照（LLb）可显著增强5-羟色胺（5-HT）受体激动剂、8-OH-DPAT和其他非光刺激诱导的仓鼠昼夜节律相位重置。本研究旨在确定LLb是否也能增强内源性5-羟色胺的相位重置反应，并加速光暗（LD）周期的大幅度提前和延迟转移。首先，通过注射l -色氨酸+/−5-羟色胺再摄取抑制剂氟西汀，中枢5-羟色胺能活性增加。ldb组和LLb组仓鼠在清晨给药或给药，释放至持续黑暗后，测量运动活动节律的相移。两种药物相移动物均未暴露于LLb （p < 0.05 vs.对照）；然而，在接受LLb治疗的动物中，l -色氨酸加氟西汀和不加氟西汀都会产生较大的相移（平均值分别为2.5±0.4h和2.6±0.2h, p<0.035）。接下来，评估LLb联合8-OH-DPAT或l -色氨酸+氟西汀对LD周期10 h相提前和相延迟位移的血清素能再夹带的影响。在未暴露于LLb的组中，载体对照组重新进入提前和延迟转移的速度较慢（平均值分别为16±1天和24±4天），而8-OH-DPAT组重新进入的速度较快（平均值分别为11±2天和9±2天；与载体组相比，p均<0.05）。在暴露于LLb的组中，车辆对照缓慢地重新进入提前和延迟转移（平均分别为15±2天和25±3天）；然而，接受8-OH-DPAT的患者迅速恢复到延迟和提前轮班，大多数（75%）只需要1 - 2天（平均值分别为2±1天和4±2天；与对照组相比，p均<0.05）。暴露于LLb和l -色氨酸+氟西汀治疗的动物也表现出加速的再夹带，提前10小时移位（平均=5±2天；与对照相比p<0.05）。因此，通过加强5 -羟色胺能相位重置，LLb促进LD周期的快速重定向，这为治疗昼夜节律相关的不同步提供了一种潜在的方法。
Brief (~2 day) constant light exposure (LLb) in hamsters dramatically enhances circadian phase-resetting induced by the serotonin (5-HT) receptor agonist, 8-OH-DPAT and other nonphotic stimuli. The present study was undertaken to determine if LLb can also amplify phase-resetting responses to endogenous 5-HT and accelerate re-entrainment to large-magnitude advance and delay shifts of the light-dark (LD) cycle. First, central serotonergic activity was increased by i.p. injection of L-tryptophan +/− the 5-HT reuptake inhibitor fluoxetine. Hamsters under LD or exposed to LLb received vehicle or drugs during the early morning, and phase-shifts of the locomotor activity rhythm were measured after release to constant darkness. Neither drug phase-shifted animals not exposed to LLb (p>0.5 vs. vehicle); however in animals receiving LLb, L-tryptophan with and without fluoxetine produced large phase-advance shifts (means=2.5±0.4h and 2.6±0.2h, respectively; both p<0.035 vs. vehicle). Next, the effects of LLb combined with 8-OH-DPAT or L-tryptophan+fluoxetine on serotonergic re-entrainment to 10 h phase-advance and phase-delay shifts of the LD cycle were assessed. In groups not exposed to LLb, vehicle controls re-entrained slowly to the advance and delay shifts (means=16±1 days and 24±4 days, respectively), but those treated with 8-OH-DPAT re-entrained faster (means=11±2 days and 9±2 days, respectively; both p<0.05 vs. vehicle). In groups exposed to LLb, vehicle controls re-entrained slowly to the advance and delay shifts (means=15±2 and 25±3 days, respectively); however those receiving 8-OH-DPAT rapidly re-entrained to the delay and advance shifts, with the majority (75%) requiring only 1–2 days (means=2±1 days and 4±2 days, respectively; both p<0.05 vs. vehicle). Animals exposed to LLb and treated with L-tryptophan+fluoxetine also exhibited accelerated re-entrainment to a 10 h advance shift (mean=5±2days; p<0.05 vs. vehicle). Thus through enhancing serotonergic phase-resetting, LLb facilitates rapid re-entrainment to large shifts of the LD cycle which offers a potential approach for treating circadian-related desynchronies.
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影响因子：
2.5
作者：
CARD, JP;MOORE, RY
通讯作者：
MOORE, RY
影响因子：
2.9
作者：
Glass, JD;DiNardo, LA;Ehlen, JC
通讯作者：
Ehlen, JC
影响因子：
64.8
作者：
JEWETT, ME;KRONAUER, RE;CZEISLER, CA
通讯作者：
CZEISLER, CA
DOI：
10.1007/bf00307084
发表时间：
1972-01-01
期刊：
ZEITSCHRIFT FUR ZELLFORSCHUNG UND MIKROSKOPISCHE ANATOMIE
影响因子：
--
作者：
HENDRICKSON, AE;WAGONER, N;COWAN, WM
通讯作者：
COWAN, WM
影响因子：
2.9
作者：
JOHNSON, RF;MORIN, LP;MOORE, RY
通讯作者：
MOORE, RY