Allergen-specific basophil reactivity exhibits daily variations in seasonal allergic rhinitis.
Allergen-specific basophil reactivity exhibits daily variations in seasonal allergic rhinitis.
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作者：
Ando N;Nakamura Y;Ishimaru K;Ogawa H;Okumura K;Shimada S;Nakao A
过敏性鼻炎的症状如何在夜间或清晨最严重仍然知之甚少。生物钟由包括Clock在内的多个“时钟基因”组成的网络驱动生理学上的每日节奏。这项研究表明，过敏原诱导的表面CD 203 c的表达在嗜碱性粒细胞在季节性变应性鼻炎引起的日本雪松花粉表现出一天的时间依赖性变化与时间的变化在典型的生物钟基因表达。我们还发现，从野生型小鼠产生的骨髓来源的嗜碱性粒细胞（BM嗜碱性粒细胞）在IgE介导的IL-4和组胺产生中表现出时间依赖性变化，这在从Clock突变小鼠产生的BM嗜碱性粒细胞中没有观察到。因此，过敏原特异性嗜碱性粒细胞的反应性表现出依赖于嗜碱性粒细胞的昼夜节律钟活动的每日变化，这可以部分解释过敏性鼻炎的时间症状变化。此外，在临床研究中解释该生物标志物时应考虑CD 203 c表达的昼夜变化。
It remains poorly understood how symptoms in allergic rhinitis are most severe during overnight or early in the morning. The circadian clock consisting of a network of several ‘clock genes’ including Clock drives daily rhythms in physiology. This study showed that allergen-induced surface CD203c expression on basophils in seasonal allergic rhinitis caused by Japanese cedar pollen exhibited a time-of-day-dependent variation associated with temporal variations in canonical circadian clock gene expression. We also found that bone-marrow-derived basophils (BM basophils) generated from wild-type mice exhibited a time-of-day-dependent variation in IgE-mediated IL-4 and histamine production, which was not observed in BM basophils generated from Clock-mutated mice. Therefore, allergen-specific basophil reactivity shows daily variations depending on the circadian clock activity in basophils, which could partly explain temporal symptomatic variations in allergic rhinitis. Additionally, circadian variations in CD203c expression should be considered for interpretation of this biomarker in clinical research.
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影响因子：
6.4
作者：
Baumann, Anja;Goennenwein, Simone;Lorentz, Axel
通讯作者：
Lorentz, Axel
DOI：
10.1038/nrg2430
发表时间：
2008-10
期刊：
Nature reviews. Genetics
影响因子：
--
作者：
通讯作者：
--
影响因子：
14.2
作者：
Hauswirth, AW;Natter, S;Valent, P
通讯作者：
Valent, P
影响因子：
2.8
作者：
Aoyagi, M;Watanabe, H;Kohno, Y
通讯作者：
Kohno, Y
影响因子：
14.2
作者：
Gelfand, Erwin W.
通讯作者：
Gelfand, Erwin W.