Innate and adaptive immunity at mucosal surfaces of the female reproductive tract: stratification and integration of immune protection against the transmission of sexually transmitted infections.
Innate and adaptive immunity at mucosal surfaces of the female reproductive tract: stratification and integration of immune protection against the transmission of sexually transmitted infections.
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DOI：
10.1016/j.jri.2011.01.005
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发表时间：
2011-03
影响因子：
3.4
通讯作者：
Wira, C. R.
中科院分区：
文献类型：
--
作者：
Hickey, D. K.;Patel, M. V.;Fahey, J. V.;Wira, C. R.
本综述探讨了多层次的预先存在的免疫力在上部和下部女性生殖道。此外，我们强调需要进一步研究女性生殖道粘膜表面的先天性和适应性免疫保护。先天机制包括粘液衬里、紧密的上皮屏障以及上皮和先天免疫细胞分泌的抗微生物肽和细胞因子。先天免疫系统的刺激还起到桥接适应性臂的作用，导致病原体特异性体液和细胞介导的免疫的产生。对以协调方式提供持续保护网络的多个组成部分了解较少。人类女性生殖道的先天性和获得性免疫受月经周期的影响，并直接受性类固醇激素孕酮和雌二醇的调节。此外，激素对免疫的作用直接介导于免疫细胞和上皮细胞，并通过刺激基质细胞分泌生长因子间接介导。本综述的目的是集中在先天性和适应性免疫系统的各个方面，有助于整个女性生殖道的独特的保护网络。
This review examines the multiple levels of pre-existing immunity in the upper and lower female reproductive tract. In addition, we highlight the need for further research of innate and adaptive immune protection of mucosal surfaces in the female reproductive tract. Innate mechanisms include the mucus lining, a tight epithelial barrier and the secretion of antimicrobial peptides and cytokines by epithelial and innate immune cells. Stimulation of the innate immune system also serves to bridge the adaptive arm resulting in the generation of pathogen-specific humoral and cell-mediated immunity. Less understood are the multiple components that act in a coordinated way to provide a network of ongoing protection. Innate and adaptive immunity in the human female reproductive tract are influenced by the stage of menstrual cycle and are directly regulated by the sex steroid hormones, progesterone and estradiol. Furthermore, the effect of hormones on immunity is mediated both directly on immune and epithelial cells and indirectly by stimulating growth factor secretion from stromal cells. The goal of this review is to focus on the diverse aspects of the innate and adaptive immune systems that contribute to a unique network of protection throughout the female reproductive tract.
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影响因子：
32.4
作者：
Hladik, Florian;Sakchalathorn, Polachai;Ballweber, Lamar;Lentz, Gretchen;Fialkow, Michael;Eschenbach, David;McElrath, M. Juliana
通讯作者：
McElrath, M. Juliana
影响因子：
3.4
作者：
Capaldo, Christopher T.;Nusrat, Asma
通讯作者：
Nusrat, Asma
影响因子：
4.4
作者：
Black, CA;Rohan, LC;Edwards, RP
通讯作者：
Edwards, RP
影响因子：
6.7
作者：
Coleman, Kimberly D.;Wright, Jacqueline A.;Fahey, John V.
通讯作者：
Fahey, John V.
DOI：
10.1034/j.1600-0897.2003.00097.x
发表时间：
2003-11-01
影响因子：
3.6
作者：
Gockel, CM;Bao, SS;Beagley, KW
通讯作者：
Beagley, KW