Long-Chain Metabolites of Vitamin E: Metabolic Activation as a General Concept for Lipid-Soluble Vitamins?
Long-Chain Metabolites of Vitamin E: Metabolic Activation as a General Concept for Lipid-Soluble Vitamins?
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DOI：
10.3390/antiox7010010
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发表时间：
2018-01-12
期刊：
影响因子：
--
通讯作者：
Lorkowski S
中科院分区：
文献类型：
--
作者：
Schubert M;Kluge S;Schmölz L;Wallert M;Galli F;Birringer M;Lorkowski S
维生素E、A、D和K构成脂溶性维生素类。对于维生素A和D，已经描述了前体向活性代谢物的代谢转化。在维生素E代谢过程中，维生素E侧链经氧化修饰形成长链代谢产物13′-羟基色原烷醇（13′-OH）和13′-羧基色原烷醇（13′-COOH）。人血清中这些代谢物的出现表明具有生理相关性。事实上，已经显示了LCM对脂质代谢、细胞凋亡、增殖和炎症作用以及生育酚和异生物质代谢的影响。有趣的是，维生素E的LCMs与维生素A和D的活性代谢物的作用之间有几个相似之处。最近的研究结果表明，LCMs发挥的作用与其前体不同，支持其作为调节代谢物的假定作用。因此，可以提出LCM的作用模式可能是由类似于维生素A和D代谢物的机制介导的。如果可以证实LCM的生理相关性和这种作用概念，则可以推导出脂溶性维生素通过其代谢物活化的一般概念。
Vitamins E, A, D and K comprise the class of lipid-soluble vitamins. For vitamins A and D, a metabolic conversion of precursors to active metabolites has already been described. During the metabolism of vitamin E, the long-chain metabolites (LCMs) 13′-hydroxychromanol (13′-OH) and 13′-carboxychromanol (13′-COOH) are formed by oxidative modification of the side-chain. The occurrence of these metabolites in human serum indicates a physiological relevance. Indeed, effects of the LCMs on lipid metabolism, apoptosis, proliferation and inflammatory actions as well as tocopherol and xenobiotic metabolism have been shown. Interestingly, there are several parallels between the actions of the LCMs of vitamin E and the active metabolites of vitamin A and D. The recent findings that the LCMs exert effects different from that of their precursors support their putative role as regulatory metabolites. Hence, it could be proposed that the mode of action of the LCMs might be mediated by a mechanism similar to vitamin A and D metabolites. If the physiological relevance and this concept of action of the LCMs can be confirmed, a general concept of activation of lipid-soluble vitamins via their metabolites might be deduced.
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影响因子：
158.5
作者：
CZEIZEL, AE;DUDAS, I
通讯作者：
DUDAS, I
影响因子：
64.8
作者：
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通讯作者：
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DOI：
10.1073/pnas.85.10.3294
发表时间：
1988-05-01
影响因子：
11.1
作者：
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通讯作者：
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DOI：
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发表时间：
2001-01-01
影响因子：
4.5
作者：
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通讯作者：
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DOI：
10.1196/annals.1331.054
发表时间：
2004-01-01
期刊：
VITAMIN E AND HEALTH
影响因子：
--
作者：
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通讯作者：
Galli, F