Photoreceptor impairment and restoration on optical coherence tomographic image.
Photoreceptor impairment and restoration on optical coherence tomographic image.
复制标题
DOI：
10.1155/2013/518170
复制
发表时间：
2013
影响因子：
1.9
通讯作者：
Yamamoto S
中科院分区：
文献类型：
--
作者：
Mitamura Y;Mitamura-Aizawa S;Katome T;Naito T;Hagiwara A;Kumagai K;Yamamoto S
随着光谱域光学相干断层扫描（SD-OCT）技术的发展，可以更详细地观察视网膜的病理变化。SD-OCT清晰地勾勒出外视网膜的三条高反射线，从内部依次为外限制膜（ELM）、光感受器内外段（IS/OS）连接处和锥外段尖端（COST）。这些谱线可以作为评价光感受器状态的标志。色素性视网膜炎（RP）导致光感受器变性，ELM、IS/OS和COST线随着疾病的进展而缩短。此外，ELM、IS/OS和COST线的缩短是相互关联的。ELM的线长最长，其次是is /OS和COST，这表明视网膜层在COST处首先变得混乱，其次是is /OS，最后是ELM。这一发现与先前的报道一致，即RP最早的组织病理学改变是光感受器外段的缩短。另一方面，视网膜层首先在ELM处恢复，其次是IS/OS，最后是COST。光学相干层析成像可能存在光感受器损伤或恢复的方向性。
With recent development of spectral-domain optical coherence tomography (SD-OCT), the pathological changes of retina can be observed in much greater detail. SD-OCT clearly delineates three highly reflective lines in the outer retina, which are external limiting membrane (ELM), photoreceptor inner and outer segment (IS/OS) junction, and cone outer segment tips (COST) in order from inside. These lines can serve as hallmarks for the evaluation of photoreceptor condition. In retinitis pigmentosa (RP) leading to photoreceptor degeneration, the ELM, IS/OS, and COST lines are shortened with the progression of the disease. In addition, shortening of the ELM, IS/OS and COST lines is significantly associated with each other. The line length is longest in the ELM, followed by the IS/OS, and COST, suggesting that retinal layer becomes disorganized first at the COST, followed by the IS/OS and finally the ELM. This finding is consistent with the previous report that the earliest histopathological change in RP is a shortening of the photoreceptor outer segments. On the other hand, retinal layer becomes restored first at the ELM, followed by the IS/OS and finally the COST after macular hole surgery. There may be a directionality of photoreceptor impairment or restoration on optical coherence tomographic image.
登录
查看更多内容
影响因子：
4.4
作者：
Sakai, T;Calderone, JB;Jacobs, GH
通讯作者：
Jacobs, GH
影响因子：
3.9
作者：
Aizawa, S.;Mitamura, Y.;Yamamoto, S.
通讯作者：
Yamamoto, S.
影响因子：
4.4
作者：
Gloesmann, M;Hermann, B;Drexler, W
通讯作者：
Drexler, W
影响因子：
4.4
作者：
Srinivasan, Vivek J.;Monson, Bryan K.;Fujimoto, James G.
通讯作者：
Fujimoto, James G.
影响因子：
4.2
作者：
Oishi, Akio;Hata, Masayuki;Kurimoto, Yasuo
通讯作者：
Kurimoto, Yasuo