The neural substrates of cognitive control deficits in autism spectrum disorders.
The neural substrates of cognitive control deficits in autism spectrum disorders.
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DOI：
10.1016/j.neuropsychologia.2009.04.019
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发表时间：
2009-10
期刊：
影响因子：
2.6
通讯作者：
Carter CS
中科院分区：
文献类型：
--
作者：
Solomon M;Ozonoff SJ;Ursu S;Ravizza S;Cummings N;Ly S;Carter CS
Executive functions deficits are among the most frequently reported symptoms of autism spectrum disorders (ASDs), however, there have been few functional magnetic resonance imaging (fMRI) studies that investigate the neural substrates of executive functions deficits in ASDs, and only one in adolescents. The current study examined cognitive control –the ability to maintain task context online to support adaptive functioning in the face of response competition—in 22 adolescents aged 12–18 with autism spectrum disorders and 23 age, gender, and IQ matched typically developing subjects. During the cue phase of the task, where subjects must maintain information online to overcome a prepotent response tendency, typically developing subjects recruited significantly more anterior frontal (BA 10), parietal (BA 7, 40), and occipital regions (BA 18) for high control trials (25% of trials) versus low control trials (75% of trials). Both groups showed similar activation for low control cues, however the ASD group exhibited significantly less activation for high control cues. Functional connectivity analysis using time series correlation, factor analysis, and beta series correlation methods provided convergent evidence that the ASD group exhibited lower levels of functional connectivity and less network integration between frontal, parietal, and occipital regions. In the typically developing group, fronto-parietal connectivity was related to lower error rates on high control trials. In the autism group, reduced fronto-parietal connectivity was related to attention deficit hyperactivity disorder symptoms.
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影响因子：
2.6
作者：
Bogte, Hans;Flamma, Bert;van Engeland, Herman
通讯作者：
van Engeland, Herman
影响因子：
2.5
作者：
Bunge, SA;Kahn, I;Wagner, AD
通讯作者：
Wagner, AD
DOI：
10.1016/s0926-6410(03)00189-7
发表时间：
2003-10-01
期刊：
COGNITIVE BRAIN RESEARCH
影响因子：
--
作者：
Belmonte, MK;Yurgelun-Todd, DA
通讯作者：
Yurgelun-Todd, DA
影响因子：
3.7
作者：
Barber, AD;Carter, CS
通讯作者：
Carter, CS
影响因子：
3.7
作者：
Brass, M;von Cramon, DY
通讯作者：
von Cramon, DY