Etiology of nasal polyps in cystic fibrosis: not a unimodal disease.
Etiology of nasal polyps in cystic fibrosis: not a unimodal disease.
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DOI：
10.1177/000348941212100904
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发表时间：
2012-09
期刊：
影响因子：
--
通讯作者：
Borish L
中科院分区：
文献类型：
--
作者：
Steinke JW;Payne SC;Chen PG;Negri J;Stelow EB;Borish L
目的是确定囊性纤维化（CF）相关鼻窦炎中观察到的息肉亚型是否与非CF相关鼻窦炎中观察到的息肉亚型相似。息肉和粘液样本采集自接受鼻窦手术的CF患者。对息肉进行了组织学和细胞化学评价，以确定淋巴细胞群及其各自的细胞因子标记物的存在。评估粘液样品的DNA含量。在息肉中，42%有嗜酸性粒细胞浸润，其中80%有额外的混合嗜酸性粒细胞浸润。在其余息肉样本中，42%没有粒细胞浸润，与非嗜酸性息肉一致。所有样本均具有CD138阳性浆细胞。来自CF患者的粘液样品显示出比来自非CF鼻窦疾病患者的粘液样品更高的细胞外DNA浓度。囊性纤维化相关息肉表现出与特发性非CF相关息肉相似的基于嗜酸性粒细胞的二分法。许多人还表现出嗜中性粒细胞浸润，表明慢性粘液淤滞和感染使疾病复杂化。能够减少细胞外DNA的药物可能有助于控制CF患者的鼻窦炎。
The objective was to determine whether the polyp subtypes observed in cystic fibrosis (CF)–related sinusitis were similar to those observed in non–CF-related sinusitis. Polyp and mucus samples were collected from CF patients who presented for sinus surgery. The polyps underwent histologic and cytochemical evaluation for the presence of lymphocyte cell populations and their respective cytokine markers. The mucus samples were evaluated for DNA content. Of the polyps, 42% had an eosinophilic infiltrate, of which 80% had an additional mixed neutrophilic infiltrate. Of the remaining polyp samples, 42% did not have a granulocytic infiltrate, consistent with non-eosinophilic polyps. All samples had CD138-positive plasma cells. The mucus samples from the patients with CF showed higher extracellular DNA concentrations than did the mucus samples from patients with non-CF sinus disease. Cystic fibrosis–related polyps demonstrated an eosinophil-based dichotomy similar to that of idiopathic non–CF-related polyps. Many also demonstrated neutrophilic infiltrate, indicating that chronic mucus stasis and infection complicate the disease. Agents capable of reducing extracellular DNA may help manage sinusitis in CF patients.
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DOI：
10.1001/archotol.131.12.1097
发表时间：
2005-12-01
影响因子：
--
作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
Bent, JP
影响因子：
56.9
作者：
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通讯作者：
Zychlinsky, A