Molecular pathophysiology of diabetes mellitus during pregnancy with antenatal complications.
Molecular pathophysiology of diabetes mellitus during pregnancy with antenatal complications.
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DOI：
10.1038/s41598-020-76689-9
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发表时间：
2020-11-12
影响因子：
4.6
通讯作者：
Morozov SG
中科院分区：
文献类型：
--
作者：
Kopylov AT;Papysheva O;Gribova I;Kotaysch G;Kharitonova L;Mayatskaya T;Sokerina E;Kaysheva AL;Morozov SG
妊娠糖尿病是一个令人生畏的问题，伴随着严重的胎儿发育并发症和产后2型糖尿病。糖尿病的诊断仅发生在妊娠中期，而相关的产前并发症通常甚至更晚才被发现。我们采集了不同类型糖尿病患者的外周血和脐带血样本，这些患者分娩了健康的新生儿或伴有胎儿病并发症。所得数据进行定性和定量分析。基于发现的标记物及其定量改变，重建了糖尿病和胎儿病相关分子事件的途径。大量的途径被整合来区分糖尿病的类型，并认识到糖尿病状况对胎儿发育的影响。受损的甘油三酯转运、葡萄糖摄取和随后的胰岛素抵抗主要受脂质代谢故障（APOM、APOD、APOH、APOC 1）的影响，并受到氧化应激（CP、TF、ORM 2）和炎症（CFH、CFB、CLU）的促进，作为伴随基质结构变化的继发性反应（AFM、FBLN 1、AMBP）。外周血和脐带血蛋白质组的改变是不相等的。上调和下调的标志物都被容纳在与脂质代谢、RXR/PPAR信号通路和细胞外结构调节相互关联的分子事件中。所获得的结果聚集了许多生物学过程的分子事件，强调妊娠期糖尿病，并揭示了影响胎儿生长和发育的一些关键方面。
Gestational diabetes mellitus is a daunting problem accompanied by severe fetal development complications and type 2 diabetes mellitus in postpartum. Diagnosis of diabetic conditions occurs only in the second trimester, while associated antenatal complications are typically revealed even later. We acquired an assay of peripheral and cord blood samples of patients with different types of diabetes mellitus who delivered either healthy newborns or associated with fetopathy complications. Obtained data were handled with qualitative and quantitative analysis. Pathways of molecular events involved in diabetes mellitus and fetopathy were reconstructed based on the discovered markers and their quantitative alteration. Plenty of pathways were integrated to differentiate the type of diabetes and to recognize the impact of the diabetic condition on fetal development. The impaired triglycerides transport, glucose uptake, and consequent insulin resistance are mostly affected by faulted lipid metabolism (APOM, APOD, APOH, APOC1) and encouraged by oxidative stress (CP, TF, ORM2) and inflammation (CFH, CFB, CLU) as a secondary response accompanied by changes in matrix architecture (AFM, FBLN1, AMBP). Alterations in proteomes of peripheral and cord blood were expectedly unequal. Both up- and downregulated markers were accommodated in the cast of molecular events interconnected with the lipid metabolism, RXR/PPAR-signaling pathway, and extracellular architecture modulation. The obtained results congregate numerous biological processes to molecular events that underline diabetes during gestation and uncover some critical aspects affecting fetal growth and development.
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影响因子：
14.9
作者：
Babicki S;Arndt D;Marcu A;Liang Y;Grant JR;Maciejewski A;Wishart DS
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Wishart DS
影响因子：
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作者：
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DOI：
10.1038/oby.2003.100
发表时间：
2003-06-01
期刊：
OBESITY RESEARCH
影响因子：
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作者：
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影响因子：
7.7
作者：
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Lindgärde, F