Helicobacter pylori: a poor man's gut pathogen?
Helicobacter pylori: a poor man's gut pathogen?
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DOI：
10.1186/1757-4749-2-2
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发表时间：
2010-03-31
期刊：
影响因子：
4.2
通讯作者：
Aziz RK
中科院分区：
文献类型：
--
作者：
Khalifa MM;Sharaf RR;Aziz RK
幽门螺杆菌是世界范围内患病率最高的人类病原体之一；然而，其主要传播方式仍然很大程度上未知。直到 20 世纪末，幽门螺杆菌在胃病和癌症中的作用才被确定。从那时起，人们对其流行病学进行了广泛的研究，越来越多的文献表明，并非所有人类都同样面临着这种肠道病原体感染的风险。在这里，我们简要回顾幽门螺杆菌感染的不同流行病学方面，重点关注与人类贫困相关的因素。幽门螺杆菌感染的流行病学特点是发展中国家和发达国家之间存在显着差异，尤其是在儿童中。此外，一致的证据表明，社会经济因素和生活水平是年龄依赖性幽门螺杆菌感染率及其患病率的主要决定因素。鉴于全球气候和出生率的变化，这些数据令人震惊，预计这将改变我们星球的人口结构，使更多的儿童在未来几年面临幽门螺杆菌及其并发症的风险。
Helicobacter pylori is one of the human pathogens with highest prevalence around the world; yet, its principal mode of transmission remains largely unknown. The role of H. pylori in gastric disease and cancer has not been established until the end of the 20th century. Since then, its epidemiology has been extensively studied, and an accruing body of literature suggests that not all humans are equally at risk of infection by this gut pathogen. Here, we briefly review the different epidemiological aspects of H. pylori infection with emphasis on those factors related to human poverty. The epidemiology of H. pylori infection is characterized by marked differences between developing and developed countries, notably among children. In addition, congruent lines of evidence point out to socioeconomic factors and living standards as main determinants of the age-dependent acquisition rate of H. pylori, and consequently its prevalence. These data are alarming in the light of the changing global climate and birth rate, which are expected to change the demography of our planet, putting more children at risk of H. pylori and its complications for years to come.
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影响因子：
3.1
作者：
Dore, MP;Bilotta, M;Realdi, G
通讯作者：
Realdi, G
影响因子：
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作者：
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通讯作者：
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影响因子：
168.9
作者：
Dore, MP;Sepulveda, AR;Graham, DY
通讯作者：
Graham, DY
DOI：
10.4269/ajtmh.1999.61.37
发表时间：
1999-07-01
影响因子：
3.3
作者：
Bassily, S;Frenck, RW;Clemens, J
通讯作者：
Clemens, J
DOI：
10.1111/j.1440-1746.1995.tb01347.x
发表时间：
1995-09-01
影响因子：
4.1
作者：
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通讯作者：
HSUHAGE, BHH