Rhabdomyolysis in Patients Hospitalized With COVID-19 Infection: Five Case Series.
Rhabdomyolysis in Patients Hospitalized With COVID-19 Infection: Five Case Series.
复制标题
DOI：
10.1177/2324709620984603
复制
发表时间：
2020-01
影响因子：
1.2
通讯作者：
Khosla R
中科院分区：
文献类型：
--
作者：
Khosla SG;Nylen ES;Khosla R
目前已知新型SARS-CoV-2病毒（严重急性呼吸综合征冠状病毒2型）可引起急性呼吸窘迫、细胞因子风暴和凝血功能障碍。在最近的文献中已经发表了多种其他表现。横纹肌溶解症是一种肌肉损伤综合征，伴随细胞内内容物释放到循环中。其特征是肌酸酐激酶水平显著升高和肌红蛋白尿。在这篇文章中，我们描述了一系列5例因COVID-19肺炎入院并有严重肌肉损伤的病例，表现为可能继发于SARS-CoV-2病毒的肌酐激酶水平显著升高（>正常上限的5倍）。这些患者的中位年龄为65岁，大多数患有糖尿病和高脂血症。所有患者均为男性高血压患者。5例患者中有4例在基线时保留了肾功能，并且是慢性肾脏疾病（CKD）2期或更好。然而，他们中的大多数人遭受了严重的肾损伤，出院时，1名患者为CKD 2期或更好，2名患者为CKD 3期或更差，2名患者因SARS-CoV-2感染并发症而死于肾衰竭。
The novel SARS-CoV-2 virus (severe acute respiratory syndrome coronavirus 2) is now known to cause acute respiratory distress, cytokine storm, and coagulopathy. Multiple other manifestations have been published in recent literature. Rhabdomyolysis is a syndrome of muscle damage, with release of intracellular contents into circulation. It is characterized by marked elevations of creatinine kinase levels and myoglobinuria. In this article, we describe a series of 5 cases who were admitted with COVID-19 pneumonia and had severe muscle injury, as demonstrated by significant elevation (>5 times upper limit of normal) of creatinine kinase levels likely secondary to SARS-CoV-2 virus. The median age for these patients was 65 years, and most of them suffered from diabetes and hyperlipidemia. All patients were hypertensive males. Four out of 5 patients had preserved kidney function at baseline and were chronic kidney disease (CKD) stage 2 or better. However, most of them suffered significant kidney injury and at the time of discharge one patient was CKD stage 2 or better, 2 were CKD stage 3 or worse, and 2 patients had renal failure and died due to complications of SARS-CoV-2 infection.
登录
查看更多内容
DOI：
10.1111/j.1368-5031.2005.00540.x
发表时间：
2005-10-01
影响因子：
2.6
作者：
Chen, LL;Hsu, CW;Fang, JT
通讯作者：
Fang, JT
DOI：
10.1016/j.ajem.2020.05.024
发表时间：
2020-07-01
期刊：
The American journal of emergency medicine
影响因子：
--
作者：
Bridwell, Rachel;Long, Brit;Gottlieb, Michael
通讯作者：
Gottlieb, Michael
影响因子：
7.5
作者：
Agyeman, P;Duppenthaler, A;Aebi, C
通讯作者：
Aebi, C
影响因子：
4.4
作者：
Sellers SA;Hagan RS;Hayden FG;Fischer WA 2nd
通讯作者：
Fischer WA 2nd
影响因子：
5.1
作者：
Ytterberg, Steven R.
通讯作者：
Ytterberg, Steven R.