The association between high levels of luteinizing hormone and proliferative retinopathy of prematurity in female preterm infants.
The association between high levels of luteinizing hormone and proliferative retinopathy of prematurity in female preterm infants.
复制标题
DOI：
10.1016/j.jaapos.2020.02.011
复制
发表时间：
2020-06
期刊：
影响因子：
--
通讯作者：
Muthusamy A
中科院分区：
文献类型：
--
作者：
Movsas TZ;Gewolb IH;Paneth N;Lu Q;Muthusamy A
黄体生成素(LH)和人绒毛膜促性腺激素(HCG)通常被认为是生殖激素，它们具有强大的促血管生成特性。这两种激素及其联合受体(CG/黄体生成素受体)都存在于人眼中。我们假设这些激素过多与早产儿增殖性视网膜病变(P-ROP)有关。干血斑点(DBS)被用来进行一项横断面研究，研究对象是2012年8月1日至2015年3月15日在密歇根州出生的患有和不患有P-ROP的婴儿(胎龄26周)。收集45例早产儿1周和4周的DBS，其中27例无ROP，18例P-ROP。DBS被与医院记录联系起来，然后被指认出来。使用ICD-9编码识别P-ROP病例。激素水平通过在中尺度发现平台上的电化学发光分析来测量。1周龄和4周龄的激素水平与P-ROP的存在或不存在之间的关系被评估。在女婴中，我们注意到ROP患者在第1周有升高的黄体生成素水平(P=0.11)，而在第4周有显著升高的趋势(P=0.03)。在男婴中，在两个时间点都没有发现与ROP相关的黄体生成素水平差异。对于hCG水平，在两个时间点都没有发现与P-ROP相关的性别。在女性而不是男性婴儿中，高促黄体生成素与P-ROP的相关性增加了存在性别特异性激素决定因素异常视网膜血管生成的可能性。
Luteinizing hormone (LH) and human chorionic gonadotropin (hCG), generally considered reproductive hormones, have potent proangiogenic properties. Both of these hormones and their joint receptor (CG/LH receptor) are found in the human eye. We hypothesized that an excess of these hormones is associated with proliferative retinopathy of prematurity (P-ROP). Dried blood spots (DBS) were used to perform a cross-sectional study of infants (gestational age of <26 weeks) with and without P-ROP, born in Michigan between August 1, 2012, and March 15, 2015. The DBS were collected at 1 week and 4 weeks of age from 45 preterm infants (27 no-ROP and 18 P-ROP). The DBS were linked to hospital records and then deidentified. ICD-9 codes were used to identify P-ROP cases. Hormones levels were measured via electrochemiluminescence assays on the Meso Scale Discovery platform. Associations between hormone levels at 1 and 4 weeks of age and the presence or absence of P-ROP were assessed. In female infants, we noted a trend toward higher LH levels in ROP cases at week 1 (P = 0.11) and significantly higher LH levels in cases at week 4 (P = 0.03). In male infants, no ROP-related differences in LH levels were found at either time point. For hCG levels, no associations with P-ROP were found in either sex at either time point. The association of high LH with P-ROP in female but not male infants raises the possibility that there are sex-specific hormonal determinants of aberrant retinal angiogenesis.
登录
查看更多内容
影响因子：
13.7
作者：
Hartnett, M. Elizabeth
通讯作者：
Hartnett, M. Elizabeth
DOI：
10.1136/archdischild-2018-316399
发表时间：
2020-03-01
影响因子：
4.4
作者：
Garfinkle, Jarred;Yoon, Eugene W.;Shah, Prakesh S.
通讯作者：
Shah, Prakesh S.
影响因子：
3.6
作者：
Benavides, Amanda;Metzger, Andrew;Nopoulos, Peg
通讯作者：
Nopoulos, Peg
影响因子：
3.8
作者：
Hirschberger RG;Kuban KCK;O'Shea TM;Joseph RM;Heeren T;Douglass LM;Stafstrom CE;Jara H;Frazier JA;Hirtz D;Rollins JV;Paneth N;ELGAN Study Investigators
通讯作者：
ELGAN Study Investigators
影响因子：
1.6
作者：
Allred, Elizabeth N.;Capone, Antonio, Jr.;Fraioli, Anthony;Dammann, Olaf;Droste, Patrick;Duker, Jay;Gise, Robert;Kuban, Karl;Leviton, Alan;O'Shea, T. Michael;Paneth, Nigel;Petersen, Robert;Trese, Michael;Stoessel, Kathleen;Vanderveen, Deborah;Wallace, David K.;Weaver, Grey
通讯作者：
Weaver, Grey