Prognostic implications of alcohol dehydrogenases in hepatocellular carcinoma.
Prognostic implications of alcohol dehydrogenases in hepatocellular carcinoma.
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乙醇脱氢酶对肝细胞癌的预后意义
DOI：
10.1186/s12885-020-07689-1
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发表时间：
2020-12-07
期刊：
影响因子：
3.8
通讯作者：
Tang R
中科院分区：
文献类型：
--
作者：
Liu X;Li T;Kong D;You H;Kong F;Tang R
肝细胞癌（HCC）是世界范围内发病率和死亡率都很高的恶性肿瘤。乙醇脱氢酶（ADH）是脱氢酶的一个大家族，与多种癌症的预后有关。然而，对肝癌中与ADH相关的预后影响的综合分析仍然缺乏，而且很大程度上是未知的。HCC的表达谱和相应的临床信息来自癌症基因组图谱（TCGA）。采用Wilcoxon符号秩检验评价ADH的表达。采用考克斯回归和Kaplan-Meier分析研究临床病理特征与生存率之间的关系。使用R/BiocManager软件包进行GO（基因本体论）和KEGG（京都基因和基因组百科全书）富集分析并可视化。我们发现，与正常肝脏样本相比，肝癌样本中ADH 1A、ADH 1B、ADH 1C、ADH 4和ADH 6的表达显著下调。单因素和多因素考克斯回归分析结果显示，ADH 1A、ADH 1B、ADH 1C、ADH 4和ADH 6的高表达是影响肝癌患者生存率的独立因素。此外，我们的Kaplan-Meier分析结果还显示，AHD 1A、ADH 1B、ADH 1C、ADH 4和ADH 6的高表达与HCC患者的良好生存率显著相关。此外，GO、KEGG和GSEA分析揭示了几种致癌信号通路与肝癌中ADH的高表达呈负相关。在本研究中，我们的研究结果为HCC患者提供了潜在的预后生物标志物或分子靶点。
Hepatocellular carcinoma (HCC) is a malignancy with high incidence and mortality rates worldwide. Alcohol dehydrogenases (ADHs) are huge family of dehydrogenase enzymes and associated with the prognosis of various cancers. However, comprehensive analysis of prognostic implications related to ADHs in HCC is still lacking and largely unknown. The expression profiles and corresponding clinical information of HCC were obtained from The Cancer Genome Atlas (TCGA). Wilcoxon signed-rank test was employed to evaluate the expression of ADHs. Cox regression and Kaplan-Meier analyses were used to investigate the association between clinicopathological characteristics and survival. GO (Gene Ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) enrichment analyses were performed and visualized using R/BiocManager package. We found that the expression of ADH1A, ADH1B, ADH1C, ADH4, and ADH6 was significantly downregulated in HCC samples compared to normal liver samples. Our univariate and multivariate Cox regression analyses results showed that high expression of ADH1A, ADH1B, ADH1C, ADH4, and ADH6 was considered as an independent factor with an improved prognosis for the survival of HCC patients. Moreover, our Kaplan-Meier analysis results also revealed that high expression of AHD1A, ADH1B, ADH1C, ADH4, and ADH6 was significantly associated with good survival rate in HCC patients. In addition, GO, KEGG, and GSEA analyses unveiled several oncogenic signaling pathways were negatively associated high expression of ADHs in HCC. In the present study, our results provide the potential prognostic biomarkers or molecular targets for the patients with HCC.
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影响因子：
11.2
作者：
Raychaudhuri P;Park HJ
通讯作者：
Park HJ
影响因子：
4.1
作者：
Abe, Hiroshi;Aida, Yuta;Aizawa, Yoshio
通讯作者：
Aizawa, Yoshio
DOI：
10.1158/1078-0432.ccr-15-0479
发表时间：
2015-11-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Karnitz LM;Zou L
通讯作者：
Zou L
影响因子：
30.8
作者：
Hashibe, Mia;Mckay, James D.;Brennan, Paul
通讯作者：
Brennan, Paul
影响因子：
2.9
作者：
Guo E;Wei H;Liao X;Xu Y;Li S;Zeng X
通讯作者：
Zeng X