Antibody Responses to Respiratory Syncytial Virus: A Cross-Sectional Serosurveillance Study in the Dutch Population Focusing on Infants Younger Than 2 Years.
Antibody Responses to Respiratory Syncytial Virus: A Cross-Sectional Serosurveillance Study in the Dutch Population Focusing on Infants Younger Than 2 Years.
复制标题
DOI：
10.1093/infdis/jiaa483
复制
发表时间：
2021-07-15
期刊：
影响因子：
--
通讯作者：
Schepp R
中科院分区：
文献类型：
--
作者：
Berbers G;Mollema L;van der Klis F;den Hartog G;Schepp R
呼吸道合胞病毒(RSV)通常导致轻微疾病，但可导致(早产儿)和老年人的严重感染。在这里，我们研究了一生中RSV特异性抗体浓度，重点是婴儿和慢性阻塞性肺疾病(COPD)患者。对42例慢性阻塞性肺疾病患者进行了来自荷兰2个全国性横断面研究(包括0-90岁年龄段的人)的血清(N- = 2655)的抗体检测和抗体亲和力测定。母体免疫球蛋白浓度下降到10-12个月龄。在出生第一年后，大约40%的儿童缺乏感染诱导的IgA抗体，因此可能没有感染。所有荷兰儿童在3岁前都表现出RSV感染的血清学证据。抗体浓度在5-9岁时达到平台期，并在一生中保持不变。与年龄匹配的健康对照组相比，COPD患者RSV特异性抗体水平和亲和力相似。一生中的RSV-IgG抗体模式可用来估计对RSV的免疫获得程度，并识别感染风险增加的人群。IgA血清阳性率可作为判断1岁以下儿童呼吸道合胞病毒感染的指标。一生中的RSV-IgG抗体模式可以用来估计对RSV的免疫程度，并识别感染风险增加的人群，而IgA血清阳性可以作为一年中儿童RSV感染的替代指标。
Respiratory syncytial virus (RSV) generally causes mild disease but can cause severe infections in (premature) infants and elderly adults. Here, we studied RSV-specific antibody concentrations throughout life with emphasis on infants and chronic obstructive pulmonary disease (COPD) patients. Sera (N = 2655) from 2 nationwide cross-sectional studies in the Netherlands including individuals aged 0–90 years were analyzed for IgG and IgA antibodies to RSV prefusion F, postfusion F, N, Ga, and Gb proteins and for antibody avidity in 42 COPD patients. Maternal IgG concentrations declined to age 10–12 months. After the first year of life, approximately 40% of children lacked infection-induced IgA antibodies and may therefore be uninfected. All Dutch children showed serological evidence of RSV infection by age 3 years. Antibody concentrations reached a plateau by age 5–9 years and remains constant throughout life. COPD patients had similar levels and avidity of RSV-specific IgG antibodies compared with age-matched healthy controls. RSV-IgG antibody patterns throughout life can be used to estimate the degree of immunity acquisition to RSV and to identify groups at increased risk of infection. Seroprevalence of IgA could be a proxy to determine RSV infection in children younger than 1 year. RSV-IgG antibody patterns throughout life can be used to estimate the degree of immunity to RSV and identify groups at increased risk of infection while IgA seroprevalence could be used as proxy for RSV infection in children < 1 year.
登录
查看更多内容
影响因子：
6.4
作者：
Bagga, Bindiya;Cehelsky, Jeffrey E.;DeVincenzo, John P.
通讯作者：
DeVincenzo, John P.
影响因子：
5.9
作者：
Graham BS
通讯作者：
Graham BS
DOI：
10.1056/nejmoa0804877
发表时间：
2009-02-05
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hall CB;Weinberg GA;Iwane MK;Blumkin AK;Edwards KM;Staat MA;Auinger P;Griffin MR;Poehling KA;Erdman D;Grijalva CG;Zhu Y;Szilagyi P
通讯作者：
Szilagyi P
影响因子：
6.4
作者：
HALL, CB;WALSH, EE;SCHNABEL, KC
通讯作者：
SCHNABEL, KC
影响因子：
5.5
作者：
Piedra, PA;Jewell, AM;Glezen, WP
通讯作者：
Glezen, WP