Ecology of the cardiovascular system: Part II - A focus on non-air related pollutants.
Ecology of the cardiovascular system: Part II - A focus on non-air related pollutants.
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DOI：
10.1016/j.tcm.2018.09.003
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发表时间：
2019-07
影响因子：
9.3
通讯作者：
Bind MA
中科院分区：
文献类型：
--
作者：
Argacha JF;Mizukami T;Bourdrel T;Bind MA
环境与心血管健康之间关系的综合经济学观点应考虑空气和非空气相关环境应激源的影响。最近，环境空气温度、室内和室外空气污染对心血管的影响进行了综述。在第二部分中，我们的目标是解决噪音，食品污染物，辐射和其他一些新兴的环境因素对心血管的影响。道路交通噪声暴露与过早动脉硬化、冠状动脉疾病和中风的风险增加有关。许多研究报告说，暴露于噪音的人患高血压的患病率增加，特别是在睡觉时。夜间噪音产生的睡眠障碍会导致神经内分泌应激反应。在噪声暴露的实验过程中观察到一些氧化和炎症内皮细胞反应。此外，在整个营养过程中，心血管系统暴露于持久性有机污染物（POP），如二恶英或杀虫剂，以及塑料相关化学品（PAC），如双酚A。流行病学研究表明，接触持久性有机污染物和活性炭与糖尿病、动脉硬化和心血管疾病的发病率之间存在正相关。持久性有机污染物和PACS具有与核受体相互作用的能力，激活不同的途径，导致氧化应激、胰岛素抵抗和血管紧张素增强。关于辐射，核爆炸幸存者患心血管疾病的风险过高。剂量-效应关系仍有争议，但低剂量辐射暴露下心血管风险增加可能令人担忧。一些新出现的环境因素，如电磁场、绿地和光照，也可能需要进一步关注。与空气无关的环境压力源也在心血管疾病负担中发挥重要作用。应制定具体的方法来评估与空气和非空气有关的污染物之间的相互作用。
An integrated exposomic view of the relation between environment and cardiovascular health should consider the effects of both air and non-air related environmental stressors. Cardiovascular impacts of ambient air temperature, indoor and outdoor air pollution were recently reviewed. We aim, in this second part, to address the cardiovascular effects of noise, food pollutants, radiation, and some other emerging environmental factors. Road traffic noise exposure is associated with increased risk of premature arteriosclerosis, coronary artery disease, and stroke. Numerous studies report an increased prevalence of hypertension in people exposed to noise, especially while sleeping. Sleep disturbances generated by nocturnal noise are followed by a neuroendocrine stress response. Some oxidative and inflammatory endothelial reactions are observed during experimental session of noise exposure. Moreover, throughout the alimentation, the cardiovascular system is exposed to persistent organic pollutants (POPs) as dioxins or pesticides, and plastic associated chemicals (PACs), such as bisphenol A. Epidemiological studies show positive associations of exposures to POPs and PACs with diabetes, arteriosclerosis and cardiovascular disease incidence. POPs and PACS share some abilities to interact with nuclear receptors activating different pathways leading to oxidative stress, insulin resistance and angiotensin potentiation. Regarding radiation, survivors of nuclear explosion have an excess risk of cardiovascular disease. Dose-effect relationships remain debated, but an increased cardiovascular risk at low dose of radiation exposure may be of concern. Some emerging environmental factors like electromagnetic fields, greenspace and light exposure may also require further attention. Non-air related environmental stressors also play an important role in the burden of cardiovascular disease. Specific methodologies should be developed to assess the interactions between air and non-air related pollutants.
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影响因子：
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通讯作者：
van de Borne, P.
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